2型糖尿病患者血清Klotho水平与冠状动脉粥样硬化的相关性

发布时间：2018-02-23 03:33

本文关键词： Klotho蛋白冠状动脉狭窄冠状动脉病变动脉粥样硬化型糖尿病　出处：《山东医药》2017年14期 　论文类型：期刊论文

【摘要】：目的探讨2型糖尿病患者血清Klotho水平与冠状动脉粥样硬化程度的关系。方法选择老年糖尿病住院患者80例,入院后行冠状动脉造影,根据造影结果分为冠心病单支病变组18例、冠心病多支病变(两支及以上)组22例及对照组40例。采用Gensini评分法对冠状动脉造影结果进行评价。应用ELISA法检测各组血清Klotho水平。分析冠心病患者冠状动脉狭窄程度与血清Klotho水平的相关性。结果对照组、冠心病单支病变组、冠心病多支病变组Gensini积分分别为(10.75±4.52)、(19.95±10.08)、(48.55±20.91)分,冠心病单支病变组、冠心病多支病变组Gensini积分均高于对照组(P均0.05),冠心病多支病变组Gensini积分高于冠心病单支病变组(P0.05)。对照组、冠心病单支病变组、冠心病多支病变组血清Klotho水平分别为(444.81±23.04)、(377.36±18.11)、(323.79±13.63)pg/m L,冠心病单支病变组、冠心病多支病变组血清Klotho水平均低于对照组(P均0.05),冠心病多支病变组血清Klotho水平均低于冠心病单支病变组(P0.05)。冠心病患者冠状动脉狭窄Gensini积分与血清Klotho水平呈负相关(r=-0.805 13,P0.05)。结果冠心病患者血清Klotho水平降低,冠状动脉狭窄Gensini积分与血清Klotho水平呈负相关,血清Klotho水平可反映糖尿病患者冠状动脉粥样硬化的程度。
[Abstract]:Objective to investigate the relationship between serum Klotho level and coronary atherosclerosis in patients with type 2 diabetes mellitus. Coronary arteriography was evaluated by Gensini scoring method in 22 patients with coronary artery disease (two or more vessel lesions) and 40 patients in control group. Serum Klotho level was measured by ELISA method. Coronary artery stenosis was analyzed in patients with coronary heart disease. The correlation between narrow degree and serum Klotho level. The Gensini scores of single vessel disease group and multivessel coronary heart disease group were 10.75 卤4.52, 19.95 卤10.08 and 48.55 卤20.91, respectively. The Gensini score of multi-vessel disease group was higher than that of control group (P 0.05), and the Gensini score of coronary heart disease group was higher than that of single vessel disease group (P 0.05). The serum Klotho levels in multivessel coronary heart disease group were 377.36 卤18.11, 323.79 卤13.63 PG / mL, respectively, and those in single-vessel coronary heart disease group were 444.81 卤23.04g / mL, 323.79 卤13.63g / mL, respectively. The serum Klotho level of coronary artery disease group was lower than that of control group (P < 0.05), and the serum Klotho level of coronary heart disease group was lower than that of coronary artery disease group (P < 0.05). The Gensini score of coronary artery stenosis and serum Klotho level were negative in patients with coronary heart disease. Results the serum Klotho level in patients with coronary heart disease was decreased. The Gensini score of coronary artery stenosis was negatively correlated with the level of serum Klotho, and the level of serum Klotho could reflect the degree of coronary atherosclerosis in diabetic patients.
【作者单位】：武汉大学人民医院;
【基金】：湖北省宜昌市医疗卫生科技计划项目(A16-301-17)
【分类号】：R587.1;R541.4

【相似文献】