间充质干细胞在骨髓增生异常综合征发生发展中的作用

发布时间：2018-02-23 17:31

本文关键词： 骨髓增生异常综合征间充质干细胞 T淋巴细胞免疫治疗　出处：《中国肿瘤生物治疗杂志》2017年09期 　论文类型：期刊论文

【摘要】：骨髓增生异常综合征(myelodysplastic syndrome,MDS)是以骨髓无效造血并伴有向急性髓系白血病转化风险为特点的一组造血系统肿瘤性疾病。肿瘤细胞的识别并清除,不仅需要肿瘤特异性T细胞的产生,还需要免疫细胞能够在肿瘤微环境中增殖以增加免疫细胞的数量从而控制肿瘤细胞。肿瘤细胞免于T细胞的清除说明MDS肿瘤细胞周围存在免疫抑制性微环境,其中,间充质干细胞(mesenchymal stem cell,MSC)促进MDS免疫抑制性微环境的形成,若能克服MSC对T细胞的抑制,将能促进免疫治疗改善MDS的治疗效果。笔者对近年来MSC(MDS-MSC)抑制T细胞在骨髓微环境中的增殖和效应功能、促进调节T细胞分化的研究进展进行回顾。
[Abstract]:Myelodysplastic syndrome (MDS) is a group of hematopoietic diseases characterized by ineffective hematopoiesis with the risk of transformation to acute myeloid leukemia. The identification and clearance of tumor cells not only requires the production of tumor-specific T cells. It is also necessary for immune cells to proliferate in tumor microenvironments to increase the number of immune cells to control tumor cells. The removal of tumor cells from T cells suggests that there is an immunosuppressive microenvironment around MDS tumor cells. Mesenchymal stem cells (MSCs) promote the formation of MDS immunosuppressive microenvironment. If MSC can overcome the suppression of T cells, In this paper, we review the recent advances in the inhibition of T cell proliferation and effect function in bone marrow microenvironment, and promote the regulation of T cell differentiation by promoting immunotherapy to improve the therapeutic effect of MDS.
【作者单位】：河北大学附属医院血液内科;广东省人民医院/广东省医学科学院华南理工大学医学院第一临床学院血液内科;
【基金】：广州市科技计划资助项目(No.20140000000-4,201400000003-1)~~
【分类号】：R551.3

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