血浆suPAR与急性冠脉综合征的相关性以及其影响因素的研究

发布时间：2018-02-25 05:09

本文关键词： 急性冠脉综合征炎症可溶性尿激酶型纤溶酶原激活物受体高敏C反应蛋　出处：《兰州大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨血浆可溶性尿激酶型纤溶酶原激活物受体(su PAR)水平与急性冠脉综合征(ACS)患者冠状动脉病变程度及其影响因素。方法:收集兰州大学第一医院心脏中心2015年3月-2016年9月因胸痛住院321例患者的基本资料,根据临床表现及冠状动脉造影结果分为急性冠脉综合征(ACS)组228例,冠状动脉造影正常的对照组93例,采用标准的酶联免疫吸附法(ELISA法)检测血浆su PAR、高敏C反应蛋白(hs-CRP)水平并进行统计学分析。结果:血浆su PAR水平是ACS发生的危险因素[OR=0.104,P0.01,95%(可信区间)CI:0.048-0.223],ACS组血浆su PAR水平高于对照组(P0.01),在ACS组中随着Gensini积分增高,血浆su PAR水平逐渐升高;根据ROC曲线获得su PAR预测ACS对应界值:1.8ug/L,敏感度0.732,特异性0.71,多元线性回归分析提示吸烟、Gensini积分、尿酸是影响血浆su PAR水平主要因素。结论:血浆su PAR水平的升高与ACS患者冠状动脉病变程度相关,且随着冠状动脉病变程度的Gensini积分升高,血浆中su PAR水平呈递增趋势,这种关系优于传统炎性标记物hs-CRP对ACS患者的预测,有可能成为预测ACS患者冠状动脉狭窄程度及危险分层的新的生物标记物。
[Abstract]:Objective: to investigate the relationship between plasma soluble urokinase plasminogen activator receptor (plasminogen activator receptor) and the severity of coronary artery disease in patients with acute coronary syndrome (ACSS) and its influencing factors. Methods: the heart center of the first Hospital of Lanzhou University was collected. Basic data of 321 patients hospitalized with chest pain from March 2015 to September 2016, According to clinical manifestations and coronary angiography results, 228 patients were divided into acute coronary syndrome (ACS) group and 93 patients with normal coronary angiography (control group). The plasma levels of su par, Gao Min C reactive protein hs-CRP were measured by standard Elisa and analyzed statistically. Results: plasma su PAR level was a risk factor for the occurrence of ACS. The average level was higher than that in the control group (P 0.01), and increased with the increase of Gensini score in the ACS group. According to the ROC curve, su PAR predicted the corresponding threshold value of ACS: 1.8ugr / L, sensitivity 0.732, specificity 0.71. Multiple linear regression analysis showed that smoking had Gensini score. Conclusion: the increase of plasma su PAR level is related to the degree of coronary artery lesion in patients with ACS, and with the increase of Gensini score of coronary artery lesion, the su PAR level in plasma tends to increase. This relationship is superior to that of traditional inflammatory marker hs-CRP in predicting ACS patients and may be a new biomarker for predicting coronary artery stenosis and risk stratification in ACS patients.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.4

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