血浆和肽素水平在慢性心力衰竭诊断中的意义

发布时间：2018-02-25 09:14

本文关键词： 和肽素慢性心力衰竭氨基末端前脑利钠肽　出处：《中国老年学杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的探讨慢性心力衰竭与血浆和肽素水平的关系及其临床意义。方法选取慢性心力衰竭患者60例(心衰组)和同期健康体检中心体检的健康人29例(正常组),比较两组和肽素及氨基末端前脑利钠肽(NT-pro BNP)水平。结果心衰组血浆和肽素水平[(16.26±2.48)pmol/L]显著高于正常组[(14.08±1.86)pmol/L,P0.001],心衰组根据其合并的基础疾病(心肌病、心房颤动、高血压、冠心病、瓣膜病、糖尿病)进行亚组分析显示,各个亚组与正常组相比,和肽素水平差异显著(P0.05)。在各心功能分级之间血浆和肽素差异均无统计学意义(P0.05);血浆NT-pro BNP水平在各心功能分级之间差异均有统计学意义(P0.05)。结论慢性心力衰竭患者血浆和肽素水平明显升高,血浆和肽素可能会成为诊断慢性心力衰竭及病情评估的一个新指标。
[Abstract]:Objective to investigate the relationship between chronic heart failure (CHF) and plasma and peptide levels and its clinical significance. Methods 60 patients with chronic heart failure (CHF group) and 29 healthy persons (normal group) were selected. Results Plasma and peptide levels in heart failure group [16.26 卤2.48 渭 mol / L] were significantly higher than those in normal group [14.08 卤1.86 pmol / L, P 0.001]. Heart failure group was based on the underlying diseases (cardiomyopathy, cardiomyopathy). A subgroup analysis of atrial fibrillation, hypertension, coronary heart disease, valvular disease and diabetes showed that each subgroup was compared with the normal group. There were no significant differences in plasma and peptide levels among different cardiac function grades, and there were significant differences in plasma NT-pro BNP levels among different cardiac function grades. Conclusion there is a significant difference in plasma NT-pro BNP levels between patients with chronic heart failure and with each grade of cardiac function. Conclusion there is no significant difference in plasma levels between patients with chronic heart failure (CHF) and patients with chronic heart failure (P 0.05). Plasma and peptide levels were significantly increased, Plasma and peptide may be a new marker for the diagnosis and assessment of chronic heart failure.
【作者单位】：大连医科大学附属第一医院特需医疗部;
【基金】：大连市科技计划项目(No.2013E15SF147)
【分类号】：R541.6

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