前列地尔对慢性阻塞性肺疾病合并肺动脉高压患者呼气冷凝液中内皮素-1、白介素-6的影响

发布时间：2018-03-02 04:34

本文关键词： 慢性阻塞性肺疾病肺动脉高压前列地尔脂微球载体制剂呼出气冷凝液内皮素- 白介素-　出处：《安徽医科大学学报》2017年06期 　论文类型：期刊论文

【摘要】：目的探讨前列地尔脂微球载体制剂(Lipo PGE1)对慢性阻塞性肺疾病(COPD)合并肺动脉高压(PH)患者呼出气冷凝液(EBC)中内皮素(ET-1)和白介素(IL-6)的影响及其临床意义。方法选择40例COPD合并PH患者,随机分为治疗组和对照组,每组20例。对照组予以抗炎、解痉、平喘、化痰、吸氧等常规治疗;治疗组在常规治疗基础上加用Lipo PGE1(10μg/d,静脉滴注,疗程10 d)。观察两组患者治疗前后EBC中ET-1和IL-6浓度、肺动脉收缩压(PASP)、动脉血PaO_2、PaCO_2、肺功能FEV_1/FVC、FEV_1/预计值等相关指标情况。结果治疗前两组患者PASP,EBC中ET-1、IL-6浓度,动脉血PaO_2、PaCO_2,肺功能FEV_1/FVC、FEV_1/预计值等相关指标差异均无统计学意义;治疗后治疗组EBC中ET-1、IL-6浓度、PASP、动脉血PaCO_2水平均低于对照组(P0.05);动脉血PaO_2、肺功能FEV_1/FVC、FEV_1/预计值水平均高于对照组(P0.05);两组患者EBC中ET-1、IL-6水平均与PASP呈正相关性(r=0.672、0.496,P0.01)。结论Lipo PGE1可以降低COPD合并PH患者EBC中的ET-1、IL-6水平,EBC中ET-1、IL-6可做为COPD合并PH疗效判断指标,具有一定临床意义。
[Abstract]:Objective to investigate the effects of prostadil lipid microsphere carrier (Lipo PGE1) on endothelin (et 1) and interleukin 6 (IL 6) in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary hypertension (COPD). Methods 40 COPD patients with PH were selected. They were randomly divided into treatment group and control group with 20 cases in each group. The control group was treated with routine therapy such as anti-inflammatory, spasmodic, antiasthmatic, phlegm reduction and oxygen inhalation, and the treatment group was given Lipo PGE1(10 渭 g / d intravenous drip on the basis of routine treatment. Before and after treatment, the concentrations of ET-1 and IL-6 in EBC, pulmonary systolic blood pressure (PASP), arterial blood PaO2C (Paco _ 2), pulmonary function FEV _ (1 / FVC) FEV _ (1 /) / predicted value were observed in both groups before and after treatment. Results the ET-1IL-6 concentration in PASP EBC of the two groups before and after treatment was observed. There was no significant difference in Pao _ 2 / Paco _ 2 and FEV / FEV _ 1 / predicted value of FEV _ C _ 1 / FEV _ C _ 1 / predicted value in the patients with arterial blood Pao _ (2) and Paco _ (2). After treatment, the levels of ET-1 IL-6 and PaCO_2 in EBC in the treatment group were lower than those in the control group (P 0.05), PaO2 in arterial blood and FEV1 / expected level in FEV1 / FEV1 / predicted level of FEV1 / FEV-1 in the treatment group were higher than those in the control group, and the levels of ET-1 IL-6 in EBC in both groups were positively correlated with PASP. Conclusion Lipo PGE1 can be decreased. The level of ET-1 and IL-6 in EBC of patients with low COPD and PH. The level of IL-6 in EBC can be used as an index to judge the curative effect of COPD with PH. It has certain clinical significance.
【作者单位】：安徽医科大学第二附属医院呼吸内科;
【基金】：安徽高校自然科学研究项目(编号:KJ2016A359)
【分类号】：R544.1;R563.9

【相似文献】