H型高血压合并冠心病患者血浆非对称性二甲基精氨酸与同型半胱氨酸的相关性

发布时间：2018-03-05 06:35

本文选题：高血压　切入点：冠心病　出处：《临床心血管病杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:探讨H型高血压合并冠心病患者血浆非对称性二甲基精氨酸(ADMA)水平与血浆同型半胱氨酸(Hcy)水平的相关性。方法:选择2016-01-2016-11于我院住院的原发性高血压病患者222例(其中单纯高血压病组66例,高血压合并冠心病组156例),采用酶联免疫吸附法检测血浆ADMA、Hcy水平。根据血浆Hcy水平,将单纯高血压组分为H型高血压亚组46例和非H型高血压亚组20例;将高血压合并冠心病组进一步分为H型高血压合并冠心病亚组104例、非H型高血压合并冠心病亚组52例。比较各组血浆ADMA水平,分析血浆ADMA与Hcy的相关性。结果:高血压合并冠心病组血浆ADMA、Hcy水平均高于单纯高血压组。H型高血压亚组血浆ADMA、Hcy水平高于非H型高血压亚组,H型高血压合并冠心病亚组血浆ADMA、Hcy水平高于非H型高血压合并冠心病亚组,差异有统计学意义(P0.05);线性相关分析显示,高血压合并冠心病患者血浆ADMA与Hcy水平有相关性(r=0.76,P0.01);进一步多元逐步回归分析显示,血浆Hcy是ADMA的影响因素。结论:H型高血压患者及H型高血压合并冠心病患者血浆Hcy、ADMA水平均高于非H型高血压患者及非H型高血压合并冠心病患者,高血压合并冠心病患者血浆ADMA水平与Hcy水平呈正相关。
[Abstract]:Objective: to investigate the relationship between plasma asymmetric dimethylarginine (ADMA) level and plasma homocysteine (Hcy) level in patients with H type hypertension complicated with coronary heart disease. Methods: selected essential hypertension patients in our hospital from 2016-01-2016-11. 222 cases (66 cases of simple hypertension group), The plasma levels of ADMA-Hcy were measured by enzyme-linked immunosorbent assay (Elisa) in 156 patients with hypertension complicated with coronary heart disease. According to the plasma Hcy level, the simple hypertension group was divided into H type hypertension subgroup (46 cases) and non-H type hypertension subgroup (20 cases). The patients with hypertension and coronary heart disease (CHD) were further divided into H type hypertension with coronary heart disease subgroup (104 cases) and non H type hypertension with coronary heart disease subgroup (52 cases). Results: the plasma levels of ADMA-Hcy in hypertensive patients with coronary heart disease were higher than those in patients with hypertension. H type hypertension subgroup was higher than that in non-H hypertension patients with coronary heart disease. The plasma ADMA-Hcy level in subgroup was higher than that in non-H type hypertension with coronary heart disease subgroup. The difference was statistically significant (P 0.05), linear correlation analysis showed that there was a correlation between plasma ADMA and Hcy levels in patients with hypertension and coronary heart disease. Conclusion Plasma Hcy levels in patients with hypertension of type H and patients with coronary heart disease are higher than those in patients with non H type hypertension and non H type hypertension with coronary heart disease. There was a positive correlation between plasma ADMA level and Hcy level in hypertensive patients with coronary heart disease.
【作者单位】：滨州医学院附属医院老年医学科;
【分类号】：R541.4;R544.1

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