改善膳食模式对北京市房山区张坊村中老年高血压患者炎性指标的影响

发布时间：2018-03-06 13:29

本文选题：高血压　切入点：饮食习惯　出处：《中国全科医学》2017年03期 　论文类型：期刊论文

【摘要】：目的通过补充抗动脉粥样硬化食疗粉,改善北京市房山区张坊村超重或肥胖高血压患者的膳食模式,观察其对患者炎性指标水平的影响。方法 2015-06-27至2015-10-11,从北京市房山区张坊村245例中老年(45~75岁)村民数据库中,选取符合纳入标准的超重或肥胖的1级高血压患者30例为研究对象。采用随机数字法将患者分为一组和二组,各15例。进行交叉干预研究,最终有24例患者(一组11例,二组13例)完成试验。分别于试验前(T0)、6周末(T1)及14周末(T2)测量患者炎性指标〔核因子κB(NF-κB)、可溶性细胞间黏附分子1(sICAM-1)、可溶性血管间黏附分子1(s VCAM-1)、E-选择素(E-Selectin)、整合素(Integrin)、脂联素(Adiponectin)、超敏C反应蛋白(hs-CRP)、空腹血糖(FBG)、空腹胰岛素(FIN)、稳态模型胰岛素抵抗指数(HOMA-IR)〕。结果一组T1时sICAM-1高于T2时,T0时NF-κB、Integrin高于T2时(P0.05)。二组T1时sICAM-1高于T2时,T0时sICAM-1、s VCAM-1高于T2时(P0.05)。T0、T1、T2时,两组NF-κB、sICAM-1、s VCAM-1、E-Selectin、Integrin、Adiponectin、hs-CRP、HOMA-IR比较,差异均无统计学意义(P0.05)。结论对于超重或肥胖的高血压患者,控制总能量摄入量,同时增加抗动脉粥样硬化食疗粉,改善膳食模式,可以降低炎性指标的水平,并可持续发挥作用,从而具有一定降低血压效果。
[Abstract]:Objective to improve the dietary pattern of overweight or obese patients with hypertension in Zhangfang Village, Fangshan District, Beijing, by supplementing anti-atherosclerosis diet powder. Methods from June 27 to October 11, 2015-06-27 to 2015-10-11, a database of 245 middle-aged and old people aged 4575 years in Zhangfang Village, Fangshan District, Beijing, was used. Thirty patients with grade 1 hypertension who met the inclusion criteria were selected. The patients were divided into one group and two groups with 15 cases each by random number method, and 24 patients (11 cases in one group) were enrolled in the cross-intervention study. The inflammatory markers (nuclear factor 魏 B, soluble intercellular adhesion molecule 1s ICAM-1, soluble vascular adhesion molecule 1s VCAM-1E- selectin, integrin integrin, lipids) were measured at the end of the 6th week and the 14th week before the trial in both groups (n = 13) and in the second group (n = 13), the inflammatory markers (nuclear factor 魏 B, soluble intercellular adhesion molecule 1) and soluble vascular adhesion molecule 1 (1) VCAM-1E- selectin, integrin, integrin, lipoprotein were measured before the trial. Adiponectinine, hypersensitive C-reactive protein hs-CRPN, fasting blood glucose FBGG, fasting insulin FINA, homeostasis model insulin resistance index (HOMA-IRN). Results the sICAM-1 at T1 was higher than that at T0 at T2 and NF- 魏 B integrin at T2 was higher than that at T2. The sICAM-1 at T1 was higher than that at T0 at T2, and the VCAM-1 at T0 was higher than that at T0. There was no significant difference between the two groups in NF- 魏 B, sICAM-1s, VCAM-1 and E-Selectinus Integrin (Adiponectinine) hs-CRPmA-IR. Conclusion for overweight or obese patients with hypertension, the total energy intake should be controlled, and the anti-atherosclerotic diet powder should be increased to improve the dietary pattern, which can reduce the level of inflammatory markers. And can continue to play a role, which has a certain effect of lowering blood pressure.
【作者单位】：首都医科大学附属北京友谊医院营养科;
【分类号】：R544.1

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