曲美他嗪联合阿托伐他汀对老年充血性心力衰竭患者血清肌钙蛋白T、心肌酶及P波离散度的影响

发布时间：2018-03-07 05:08

本文选题：曲美他嗪　切入点：阿托伐他汀　出处：《中国老年学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨曲美他嗪联合阿托伐他汀对老年充血性心力衰竭(CHF)患者血清肌钙蛋白T(TnT)、心肌酶及P波离散度(Pd)的影响。方法老年CHF患者89例,根据随机对照表分为对照组和试验组,其中试验组45例,对照组44例,两组均卧床休息,给予常规入院检查,并给予降血压、维持电解质平衡等对症治疗,实施抗菌、β受体阻滞剂、强心剂、利尿剂以及抗血小板制剂等常规对症治疗药物,应用洋地黄类药物治疗,试验组在此基础上应用曲美他嗪联合阿托伐他汀治疗,密切监护患者血常规、肝肾功能以及心电图,治疗结束后对比分析两组左室射血分数(LVEF)、左室舒张末内径(LVEDD)、6 min步行试验、血清TnT、心肌酶及Pd。结果治疗后试验组与对照组相比总有效率较高(P0.05),LVEDD较低,LVEF、6 min步行试验距离高,血清(TnT)水平较低,肌酸激酶(CK)、CK同工酶(CK-MB)、乳酸脱氢酶(LDH)水平较低,P波最大宽度(Pmax)、Pd、P波最小宽度(Pmin)水平较低(P0.05)。结论曲美他嗪联合阿托伐他汀对老年CHF患者优于常规治疗,提升LVEF,改善心功能,缓解病情发展,预防心肌重构,阻止病情的进一步恶化,改善临床症状。
[Abstract]:Objective to investigate the effects of trimetazidine combined with Atto vastatin on serum troponin TnTn, myocardial enzyme and P-wave dispersion (PD) in elderly patients with congestive heart failure (CHF). There were 45 cases in the test group and 44 cases in the control group. The two groups were all in bed rest, received routine admission examination, and were treated with antiseptic, 尾 receptor blocker, cardiopressin, and other symptomatic treatment, such as lowering blood pressure and maintaining electrolyte balance. Diuretics and antiplatelet agents were used as routine symptomatic drugs, digitalis were used, and trimetazidine combined with Atto vastatin was used in the trial group to closely monitor the patients' blood routine, liver and kidney function, and electrocardiogram (ECG). After treatment, the left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVED) 6 min walking test, serum TNT, myocardial enzyme and PD were compared between the two groups. Results the total effective rate of the trial group was higher than that of the control group, and the distance of LVEF6 min walking test was higher than that of the control group. The level of serum TnT was lower, the level of CK isoenzyme CK-MBH and lactate dehydrogenase (LDH) was lower, the maximum width of P wave and the minimum width of P wave were lower (P 0.05). Conclusion trimetazidine combined with Atto vastatin is superior to routine therapy in elderly patients with CHF. Improve LVEF, improve cardiac function, alleviate the development of the disease, prevent myocardial remodeling, prevent the further deterioration of the disease and improve the clinical symptoms.
【作者单位】：厦门大学附属第一医院干部保健病房;
【基金】：国家自然科学基金(No.81641020)
【分类号】：R541.61

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