阿魏酸钠对老年冠心病患者血管内皮保护作用及对妊娠相关血浆蛋白A水平、核转录因子-κB活性的影响

发布时间：2018-03-09 21:27

本文选题：阿魏酸钠　切入点：冠心病　出处：《中国老年学杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的探讨阿魏酸钠对冠心病患者妊娠相关血浆蛋白(PAPP)-A水平、核因子(NF)-κB活性的影响。方法选择冠心组患者92例,其中包括不稳定型心绞痛患者36例,急性心肌梗死患者29例和稳定型心绞痛患者27例。并选取健康志愿者(健康组)70例。采用酶联免疫吸附法(ELISA)检测PAPP-A水平及NF-κB活性。结果与健康组相比,冠心病患者PAPP-A水平及(健康组)NF-κB活性明显增噶高(P0.01)。阿魏酸钠治疗后冠心病患者PAPP-A水平及NF-κB活性均明显下降(P0.01)。且不稳定型心绞痛患者与急性心肌梗死患者PAPP-A水平与NF-κB活性正相关(P0.01)。结论阿魏酸钠通过抑制炎症反应,减少氧化应激反应,而能够对心血管起到保护作用。
[Abstract]:Objective to investigate the effects of sodium ferulate on the levels of PAPPfi-A and the activity of nuclear factor NF-kappa B in pregnancy-associated plasma in patients with coronary heart disease. Methods 92 patients with coronary heart disease were selected, including 36 patients with unstable angina pectoris. Twenty-nine patients with acute myocardial infarction (AMI) and 27 patients with stable angina pectoris (AMI) were enrolled in this study. The level of PAPP-A and the activity of NF- 魏 B were detected by Elisa in 70 healthy volunteers. The level of PAPP-A and the activity of NF- 魏 B in patients with coronary heart disease were significantly increased after sodium ferulate treatment. The level of PAPP-A and the activity of NF- 魏 B were significantly decreased in patients with coronary heart disease after treatment with sodium ferulate. The levels of PAPP-A in patients with unstable angina pectoris and patients with acute myocardial infarction were significantly lower than those in patients with acute myocardial infarction and unstable angina pectoris. The activity of NF- 魏 B was positively correlated with that of P0.01.Conclusion Sodium ferulate inhibits inflammatory response, Reduce oxidative stress and can protect the cardiovascular system.
【作者单位】：山东省交通医院;
【分类号】：R541.4

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