曲美他嗪联合运动疗法对冠心病经皮冠状动脉介入术后患者心脏康复的影响

发布时间：2018-03-10 14:53

本文选题：曲美他嗪　切入点：运动疗法　出处：《中国医院药学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的:探讨曲美他嗪联合运动疗法对冠心病经皮冠状动脉介入(PCI)术后患者心脏康复作用的影响。方法:纳入冠心病PCI术后1个月内的患者90例,随机分成治疗A组、治疗B组及对照组,每组各30例。A组在冠心病二级预防治疗的基础上加用曲美他嗪并联合运动疗法、B组在冠心病二级预防治疗的基础上加用曲美他嗪、对照组仅给予冠心病二级预防治疗。观察期为6个月。监测3组患者的6 min步行试验(6MWT)的距离、6MWT时的心率及动脉血氧饱和度、左室舒张末期内径(LVEDD)、左室收缩末期内经(LVESD)、左室间隔厚度(LVIVS)、左心室后壁厚度(LVPWT)、左室射血分数(LVEF)及正常舒张功能的比例。结果:组内比较:与治疗前相比,3组的6MWT的距离明显增多、6MWT时的心率明显降低、正常舒张功能的比例明显升高并且LVEF明显增加,差异具有统计学意义(P0.05)。治疗后组间比较:A组分别与B组及对照组相比,6MWT的距离明显增加、6MWT时的心率明显降低、正常舒张功能的比例明显升高且左室射血分数明显增加,差异具有统计学意义(P0.017);B组与对照组相比,治疗后LVEF明显增加,差异具有统计学意义(P0.017),6MWT的距离、6MWT时的心率及正常舒张功能的比例两组无明显改善(P0.05)。结论:曲美他嗪联合运动疗法对冠心病PCI术后患者的心脏康复效果优于常规的冠心病二级预防治疗。
[Abstract]:Objective: to investigate the effect of trimetazidine combined with exercise therapy on cardiac rehabilitation in patients with coronary heart disease after percutaneous coronary intervention (PCI). In group B and control group, 30 cases in each group were treated with trimetazidine combined with exercise therapy on the basis of secondary prophylaxis of coronary heart disease, and trimetazidine was added in group B on the basis of secondary prophylaxis of coronary heart disease. The control group was only treated with secondary prophylaxis of coronary heart disease. The observation period was 6 months. The heart rate and arterial oxygen saturation were monitored during 6 min walking test (6 MWT) and 6 MWT. Left ventricular end-diastolic diameter (LVEDDN), left ventricular end-systolic dimension (LVESD), left ventricular septal thickness (LVIVSN), left ventricular posterior wall thickness (LVPWTT), left ventricular ejection fraction (LVEF) and normal diastolic function were compared. The heart rate decreased significantly when the distance increased significantly by 6MWT. The ratio of normal diastolic function and LVEF were significantly increased, the difference was statistically significant (P 0.05). After treatment, compared with group B and control group, the heart rate of group A was significantly lower than that of group B, and the distance between group A and group B was significantly higher than that of group B and control group (P < 0.05). The ratio of normal diastolic function and left ventricular ejection fraction were significantly increased. The difference was statistically significant. Compared with the control group, LVEF in group B was significantly higher than that in control group. There was no significant difference in heart rate and normal diastolic function between the two groups under 6MWT. Conclusion: the effect of combined exercise therapy with trimetazidine on cardiac rehabilitation after PCI is better than that of routine therapy. Secondary prophylaxis for coronary heart disease.
【作者单位】：江汉大学附属医院;
【基金】：武汉市科技局项目(编号:200951999575)
【分类号】：R541.4

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