内皮型一氧化氮合成酶基因rs3918181多态性与贵州省苗族、布依族原发性高血压的关系

发布时间：2018-03-10 17:31

本文选题：原发性高血压　切入点：一氧化氮合酶　出处：《临床心血管病杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的:探讨贵州省苗族、布依族人群内皮型一氧化氮合成酶(eNOS)基因第14内含子rs3918181位点多态性与原发性高血压的关系。方法:选取贵州雷山县苗族和荔波县布依族247例原发性高血压患者(苗族123例,布依族124例)为高血压组,244例健康人群(苗族118例,布依族126例)为对照组。采用TaqMan探针法检测eNOS基因rs3918181位点多态性,分析rs3918181位点不同基因型及等位基因频率在两个民族人群中的分布。结果:eNOS基因rs3918181位点AA、AG、GG基因型及A、G等位基因在苗族、布依族高血压组与对照组中的分布频率符合Hardy-Weinberg平衡定律;贵州苗族、布依族人群eNOS基因rs3918181位点基因型分布频率及等位基因频率在高血压组和健康对照组之间差异无统计学意义。结论:eNOS基因rs3918181位点多态性与贵州省苗族、布依族人群原发性高血压可能不相关,该位点多态性在贵州苗族、布依族人群之间无民族差异性。
[Abstract]:Objective: to study the Miao nationality in Guizhou Province, Relationship between rs3918181 polymorphism in intron 14 of endothelial nitric oxide synthase (Enos) gene and essential hypertension in Buyi ethnic group methods: 247 patients with essential hypertension were selected from Miao nationality and Buyi nationality of Libo County, Guizhou Province, and 123 cases from Miao nationality, Miao nationality, Libo County, Guizhou Province, China. 124 cases of Buyi nationality were divided into hypertension group (n = 244) and healthy population (n = 118 Miao, n = 126). The polymorphism of eNOS gene rs3918181 locus was detected by TaqMan probe method. The distribution of different genotypes and alleles of rs3918181 locus in two ethnic groups was analyzed. Results the distribution of rs3918181 locus AAGG genotype and Agno G allele in Miao nationality, Buyi nationality hypertension group and control group were in accordance with the equilibrium law of Hardy-Weinberg. There was no significant difference in the genotype distribution and allelic frequency of eNOS rs3918181 locus between Guizhou Miao and Buyi ethnic groups. Conclusion there is no significant difference in the rs3918181 polymorphism of eNOS gene between the hypertension group and the healthy control group. There may be no correlation between essential hypertension and the polymorphism of this locus in Guizhou Miao and Buyi ethnic groups.
【作者单位】：地方病与少数民族疾病教育部重点实验室;贵州省医学分子生物学重点实验室(贵州医科大学);
【基金】：国家科技支撑计划项目(No:2013BAI05B03) 贵州省“2011协同创新中心”[No:黔教合协同创新中心(2014)06号]
【分类号】：R544.11

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