通心络胶囊联合前列腺素E1对PCI患者的效果及对内皮功能的影响

发布时间：2018-03-10 19:18

本文选题：通心络胶囊　切入点：前列腺素E　出处：《中药药理与临床》2017年04期 　论文类型：期刊论文

【摘要】：目的:探究通心络胶囊联合前列腺素E1对经皮冠状动脉介入治疗(PCI)患者的治疗效果以及对患者内皮功能的影响。方法:选取我院2015年2月~2016年4月收治的PCI患者90例,随机分为两组,对照组应用前列腺素E1治疗,观察组联合应用通心络胶囊治疗,比较两组患者治疗效果及对内皮功能的影响。结果:治疗前两组患者的血液流变学相关指标无明显区别,治疗后均得到一定改善,观察组显著优于对照组;治疗前两组患者的超敏C反应蛋白(hs-CRP)以及白介素6(IL-6)无明显区别,治疗后均得到一定改善,观察组显著低于对照组;治疗前两组患者的血浆一氧化氮(NO)、内皮素-1(ET-1)以及内源性地高辛样因子(EDF)比较无明显区别,治疗后均得到一定改善,观察组显著优于对照组。结论:通心络胶囊联合前列腺素E1的治疗可以改善PCI患者治疗效果,提高患者血管内皮功能。
[Abstract]:Objective: to investigate the effect of Tongxinluo capsule combined with prostaglandin E 1 on the treatment of patients with percutaneous coronary intervention (PCI) and its effect on endothelial function. Methods: 90 patients with PCI were selected from February 2015 to April 2016 in our hospital. They were randomly divided into two groups: the control group was treated with prostaglandin E1 and the observation group was treated with Tongxinluo capsule. Results: before treatment, there was no significant difference in hemorheological parameters between the two groups, and there was a certain improvement after treatment, and the observation group was significantly better than the control group. Before treatment, there was no significant difference between the two groups in hypersensitive C-reactive protein hs-CRP and interleukin-6 IL-6. After treatment, the two groups were improved to some extent, the observation group was significantly lower than the control group. Plasma nitric oxide (no), endothelin-1 (ET-1) and endogenous digoxigenin-like factor (EDF) were not significantly different between the two groups before and after treatment. Conclusion: Tongxinluo capsule combined with prostaglandin E1 can improve the therapeutic effect of PCI patients and improve vascular endothelial function.
【作者单位】：湖南省人民医院;湘雅医学院附属三医院;
【基金】：湖南省人民医院仁术基金(2008-16):前列腺素E1对PCI木后患者心血管事件的影响及其机理研究
【分类号】：R541.4

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