红细胞压积及其与空腹血糖、血尿酸的交互作用对高血压患病风险的影响

发布时间：2018-03-13 10:28

本文选题：高血压　切入点：红细胞压积　出处：《山东医药》2017年30期 　论文类型：期刊论文

【摘要】：目的探讨红细胞压积(HCT)及其与空腹血糖(FBG)、血清尿酸(SUA)的交互作用对高血压患病的影响,为高血压的预防提供依据。方法采用横断面研究,选取2011年在徐州市中心医院体检者32 631例。采集空腹肘静脉血,测定FBG、SUA、肝功能指标(ALT、AST)、血脂(TC、TG、HDL-C)及HCT,并检查患者的血压。将不同性别受检者的HCT按照四分位数分为Q1、Q2、Q3、Q4四个水平,按照FBG三分位数分为低、中等、高三个水平,按照SUA三分位数分为低、中等、高三个水平。用Pearson检验计算HCT与FBG、SUA间的相关性,采用多元线性回归、Logistic回归和最大似然法分层分析趋势性及交互作用。结果随着HCT增加,高血压的患病率由Q1的23.9%上升到Q4的30.6%,高血压的患病风险增加(趋势P0.01)。SUA低水平、高水平者的HCT与高血压患病风险的关联性差异无统计学意义趋势(P=0.099)。在FBG的各水平上,高血压患病风险均随HCT的增高而增高(趋势P分别为0.001、0.001、0.040)。SUA、FBG与HCT共同对高血压的患病风险起作用(交互作用P分别为0.001、0.001)。结论 HCT与高血压病患病密切相关,且与FBG、SUA存在交互作用,共同影响高血压的患病。
[Abstract]:Objective to investigate the effect of HCT and its interaction with FBGG (fasting blood glucose) and serum uric acid (UAA) on the prevalence of hypertension, and to provide a basis for the prevention of hypertension. In 2011, 32 631 patients were examined in Xuzhou Central Hospital. Fasting elbow venous blood was collected, liver function index (alt) ASTU, liver function index (alt), TGG (HDL-C) and HCT were measured, and blood pressure of patients was examined. The HCT of patients with different sex was divided into 4 levels according to quartile number of Q1Q2Q3Q4, according to Q1Q2Q3Q4 level, the patients were divided into 4 levels according to Q1Q2Q3Q4 level. According to the three digits of FBG, they were divided into three levels: low, medium and high, according to the three digits of SUA. The correlation between HCT and FBG SUA was calculated by Pearson test. Results with the increase of HCT, the prevalence of hypertension increased from 23.9% of Q1 to 30.6 of Q4, and the risk of hypertension increased (P0.01SUA). There was no significant difference in the correlation between HCT and hypertension risk in high level subjects. There was no significant trend in the relationship between HCT and hypertension risk. At all levels of FBG, there was no significant difference in the risk of hypertension. The risk of hypertension increased with the increase of HCT (P < 0. 001). The risk of hypertension was affected by HCT and HCT (P = 0. 001). Conclusion HCT is closely associated with hypertension and has an interaction with FBGG SUA. Affect the prevalence of high blood pressure.
【作者单位】：徐州市中心医院;
【分类号】：R544.1

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