心舒宁合剂对舒张性心力衰竭患者BNP、CA125和CRP的影响分析

发布时间：2018-03-17 13:01

本文选题：心舒宁合剂　切入点：舒张性心力衰竭　出处：《中国现代医学杂志》2017年19期 　论文类型：期刊论文

【摘要】：目的探讨心舒宁合剂辅助治疗舒张性心力衰竭(DHF)患者的临床效果及对患者外周血脑钠肽(BNP)、糖类抗原125(CA125)和C反应蛋白(CRP)的影响。方法选取2015年1~12月该院心血管内科收治的DHF患者120例,根据就诊顺序随机分为心舒宁组和常规组各60例。两组均采用西医基础治疗,心舒宁组同时给予心舒宁合剂辅助治疗,疗程2个月,对比临床效果。结果治疗后,心舒宁组与常规组比较,6 min步行距离、心脏彩超E峰/A峰和左室射血分数均高于常规组,差异有统计学意义(t=3.767、3.866和5.474,P=0.000、0.000和0.000);心舒宁组的等容舒张时间低于常规组,差异有统计学意义(t=8.36,P=0.000);心舒宁组外周血BNP、CA125和CRP水平低于常规组,差异有统计学意义(t=3.456、6.317和6.939,P=0.003、0.000和0.000);治疗2个月后,心舒宁组的总有效率95.00%(57/60)高于常规组81.67%(49/60),差异有统计学意义(χ2=5.175,P=0.023)。结论心舒宁合剂辅助治疗DHF患者能够提高患者的心功能水平,降低外周血BNP、CA125和CRP水平,提高临床治疗效果。
[Abstract]:Objective to investigate the clinical effect of Xinshuning mixture in the treatment of patients with diastolic heart failure (DHFV) and its effects on the patients with peripheral blood brain natriuretic peptide (BNPP), carbohydrate antigen 125 (CA125) and C-reactive protein (CRP). Methods from 2015 to December, the patients were selected from the Department of Cardiovascular Medicine in our hospital. 120 patients with DHF, According to the order of visit, the patients were randomly divided into two groups: Xinshuning group (n = 60) and routine group (n = 60). Both groups were treated with basic western medicine, and Xinxuning mixture was treated with Xinxuning mixture for 2 months. Compared with the control group, the walking distance at 6 min, peak E / A and left ventricular ejection fraction in Xinshuning group were higher than those in the routine group, and the difference was statistically significant (P < 0.05), and the isovolumic diastolic time of Xinxuning group was lower than that of the routine group. The levels of BNPCA125 and CRP in the peripheral blood of Xinshuning group were lower than those in the routine group, and the differences were statistically significant. The total effective rate of Xinshuning group (95.00 / 60) was significantly higher than that of the routine group (81.67 / 49 / 60) (蠂 ~ 2 / 5.175). Conclusion the cardiac function of patients with DHF treated with Xinshuning mixture can improve the level of cardiac function, decrease the levels of BNPCA125 and CRP in peripheral blood, and improve the clinical therapeutic effect.
【作者单位】：贵阳中医学院第一附属医院心血管内科;
【分类号】：R541.6

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