血脂康联合依折麦布对糖尿病前期不稳定性心绞痛患者糖代谢的影响

发布时间：2018-03-17 21:42

本文选题：血脂康　切入点：依折麦布　出处：《中国现代医学杂志》2017年25期 　论文类型：期刊论文

【摘要】：目的观察血脂康联合依折麦布对糖尿病前期不稳定性心绞痛患者的糖代谢影响。方法糖尿病前期不稳定性心绞痛患者210例。随机分为A组和B组,常规治疗基础上,A组加用阿托伐他汀40 mg;B组加用血脂康胶囊1.2 g和依折麦布10 mg治疗1、6和12个月,比较空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、新发糖尿病例数变化,以及超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子(TNF-α)等。结果 (1)A组治疗6和12个月时的FBG较基线升高;B组治疗6和12个月时的FBG,1、6和12个月时的2h PG,12个月时的Hb A1c较基线和与A组比较,均差异有统计学意义(P0.05)。(2)A组治疗1、6和12个月时的hs-CR P,12个月时的IL-6、TN F-α较基线下降;B组治疗1、6和12个月时的hs-CR P、TN F-α、6和12个月时的IL-6较基线和与A组比较,均差异有统计学意义(P0.05)。结论血脂康联合依折麦布通过抗炎作用改善糖尿病前期不稳定性心绞痛患者糖代谢。
[Abstract]:Objective to observe the effect of Xuezhikang combined with ezeimebum on glucose metabolism in patients with prediabetic unstable angina pectoris. Methods 210 patients with prediabetic unstable angina pectoris were randomly divided into group A and group B. On the basis of routine therapy, group A was treated with Atto vastatin 40 mg / g and Xuezhikang capsule 1.2 g and Ezeimebum 10 mg for 1, 6 and 12 months respectively. Fasting blood glucose (FBG), 2 h postprandial blood glucose and 2 h plasma glucose, HbA1cn, and the number of newly diagnosed diabetes were compared. The results showed that FBG in group A was higher than that in group B at 6 and 12 months after treatment, and that in group B at 6 and 12 months, and that in group B at 12 months, and that in group B at 12 months, and that in group B was higher than that in group B at 6 and 12 months, and at 12 months, HB in group A was higher than that in group B at 6 and 12 months, and in 12 months of treatment, the levels of hs-CRP, IL-6 and TNF- 伪 were higher than those in group B at 6 and 12 months, respectively. A1c compared to baseline and group A, The differences were statistically significant in hs-CR P6 and 12 months in group A, IL-6 TN F- 伪 in group B at 12 months and IL-6 in group B at 1 and 12 months, compared with baseline and group A at 12 months, respectively. Conclusion Xuezhikang combined with Ezeimebum can improve glucose metabolism in patients with prediabetic unstable angina pectoris through anti-inflammatory effect.
【作者单位】：河南省开封市中心医院心内科;
【基金】：开封市科技创新人才计划项目(No:汴科文[2016]124号) 开封市创新型科技团队计划项目(No:汴科文[2016]124号)
【分类号】：R541.4;R587.1

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