孤立性房颤患者不对称二甲精氨酸水平变化的临床研究

发布时间：2018-03-18 13:09

本文选题：孤立性房颤　切入点：不对称二甲精氨酸水平　出处：《南京医科大学学报(自然科学版)》2017年11期 　论文类型：期刊论文

【摘要】：目的:研究孤立性房颤(lone atrial fibrillation,LAF)患者不对称二甲精氨酸水平(asymmetric dimethylarginine,ADMA)的变化,探讨其内皮功能损害的特点。方法:选取在2014年12月—2017年1月80例符合入组条件的LAF病例为LAF组,选择同期体检的窦性心律志愿者80例为对照组。所有病例均以酶联免疫吸附双抗体夹心法(ELISA)检测ADMA水平。结果:两组在年龄、性别等临床资料比较,差异无统计学意义(P0.05),LAF组静息心率、体重指数、左房内径、ADMA大于对照组,差异有统计学意义(P0.05);对于所有研究对象多因素回归分析提示房颤、心率、吸烟、胆固醇值是预测ADMA升高的独立危险因素(P0.01);对于LAF组病例多因素回归分析提示房颤持续时间、吸烟、胆固醇值是预测ADMA升高的独立危险因素(P0.05或0.01)。结论:LAF同样可以引起全身血管内皮损害;房颤持续时间、吸烟、胆固醇值是房颤患者内皮功能受损程度的重要预测因子。
[Abstract]:Objective: to study the changes of asymmetric dimethylarginine (ADMA) level and the characteristics of endothelial dysfunction in patients with solitary atrial fibrillation lone atrial fibrillation (LAFA). Methods: from December 2014 to January 2017, 80 patients with LAF were selected as LAF group. 80 sinus rhythm volunteers who were examined at the same time were selected as the control group. All the patients were tested for ADMA by Elisa. Results: the clinical data of the two groups were compared in terms of age, sex and other clinical data. There was no significant difference in resting heart rate, body mass index (BMI), left atrial diameter (ADMA) in LAF group (P 0.05), and the difference was statistically significant (P 0.05). Cholesterol level was an independent risk factor for predicting the increase of ADMA, and multivariate regression analysis in LAF group suggested that AF duration and smoking were observed. Cholesterol level was an independent risk factor for predicting the increase of ADMA (P0.05 or 0.01). Conclusion: 1% LAF can also cause systemic vascular endothelial damage, atrial fibrillation duration, smoking and cholesterol level are important predictors of endothelial dysfunction in patients with atrial fibrillation.
【作者单位】：连云港市第二人民医院心血管内科;
【基金】：连云港市“521工程”资助项目
【分类号】：R541.75

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