老年非糖尿病高血压患者尿微量白蛋白与颈动脉硬化相关性分析

发布时间：2018-03-19 00:32

本文选题：原发性高血压　切入点：尿微量白蛋白　出处：《临床心血管病杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的:探讨老年非糖尿病原发性高血压患者尿微量白蛋白(MAU)与颈动脉硬化的相关性。方法:选取老年非糖尿病原发性高血压患者142例,根据24h尿MAU量分为正常组78例(MAU30 mg/24h)和MAU组64例(MAU 30~300mg/24h)。比较两组患者颈动脉内膜中层厚度(CIMT)、CIMT增厚率以及颈动脉斑块发生率。结果:BMI、总胆固醇(CHOL)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)在MAU组中均高于正常组,差异具有统计学意义(均P0.05);CIMT、CIMT增厚率以及颈动脉斑块发生率在MAU组均高于正常组,差异具有统计学意义(均P0.05);MAU量与HbA1c(r=0.205,P=0.014)和CIMT值(r=0.294,P=0.000)呈正相关性。结论:老年非糖尿病高血压患者MAU与颈动脉硬化相关,可能是颈动脉硬化的危险因素。
[Abstract]:Objective: to investigate the relationship between urinary microalbuminuria (MAU) and carotid arteriosclerosis in elderly patients with non-diabetic essential hypertension. Methods: 142 elderly patients with non-diabetic essential hypertension were selected. According to 24-hour urinary MAU volume, 78 cases of normal group and 64 cases of MAU group were divided into normal group (n = 78) and MAU group (n = 64). The thickening rate of carotid intima-media thickness and the incidence of carotid plaque were compared between the two groups. LDL-Con, HbA1c) in MAU group were higher than those in normal group. The difference was statistically significant (P 0.05). The thickening rate of CIMT and the incidence of carotid plaque in MAU group were higher than those in normal group. There was a positive correlation between MAU and carotid arteriosclerosis in elderly patients with non-diabetic hypertension (P < 0.05), and there was a positive correlation between MAU and HbA1cU (P < 0.014) and CIMT value (P = 0.294). Conclusion: MAU may be a risk factor for carotid atherosclerosis in elderly patients with non-diabetic hypertension.
【作者单位】：甘肃省人民医院干三心内科;
【分类号】：R543.4;R544.11

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