高血压患者发生急性冠状动脉综合征相关临床和生化标记物因素分析

发布时间：2018-03-20 14:31

本文选题：高血压　切入点：急性冠状动脉综合征　出处：《中国循环杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的:分析原发性高血压患者发生急性冠状动脉综合征(ACS)与炎性因子和相关高危因素的关系,并探讨其临床意义。方法:选择符合纳入标准的原发性高血压组患者79例,原发性高血压并发ACS组患者85例,选取健康人48例作为对照组,测定每组患者的相关临床生化指标和血清脂蛋白相关磷脂酶A2(LP-PLA2)、类胰蛋白酶(TPS)水平,统计每组患者的心血管疾病危险因素,运用Logistic回归分析上述生化指标、炎性因子和危险因素对原发性高血压患者并发ACS的意义。结果 :纤维蛋白原(Fbg)、超敏C反应蛋白(hs-CRP)、TPS和动脉粥样硬化(AS)斑块、LP-PLA2、原发性高血压分级的OR值均大于1,其中Fbg是最有意义的独立危险因素(OR:22.242,95%CI:6.458~76.609,P0.001),其标化偏回归系数b’绝对值在6个变量中最大(b’:1.079),对原发性高血压患者发生ACS的影响最大。结论:Fbg、hs-CRP、LP-PLA2、TPS和动脉粥样硬化斑块、原发性高血压分级是原发性高血压患者发生ACS的重要独立危险因素,其中Fbg是原发性高血压发生ACS最强的独立危险因素,Fbg对原发性高血压患者发生ACS的影响最大,为ACS的预防或治疗提供了新的方向。
[Abstract]:Objective: to analyze the relationship between acute coronary syndromes (ACSs) and inflammatory factors and related high risk factors in patients with essential hypertension, and to explore its clinical significance. 85 patients with essential hypertension complicated with ACS and 48 healthy persons were selected as control group. The clinical biochemical indexes and serum lipoprotein associated phospholipase A2LP-PLA2, trypsin like trypsin levels were measured in each group. The risk factors of cardiovascular disease in each group were analyzed, and the above biochemical indexes were analyzed by Logistic regression analysis. The significance of inflammatory factors and risk factors in ACS in patients with essential hypertension. Results: the OR values of fibrinogen FbgP, hypersensitive C-reactive protein (hs-CRP), Atherosclerotic plaques (LP-PLA2), and grade of essential hypertension (EH) were higher than 1 (P < 0.01). Middle Fbg is the most significant independent risk factor, and the most significant independent risk factor is O: 22.242 / 95CI: 6.458 / 76.609 / P0.001.The absolute value of the standardized partial regression coefficient (b') is the largest in 6 variables, and the largest of the six variables (BX: 1.079) has the greatest effect on the occurrence of ACS in patients with essential hypertension. Conclusion: Fbghs-CRPP-PLA2TPS and atherosclerotic plaques are the most important factors affecting the occurrence of ACS in patients with essential hypertension. The grade of essential hypertension is an important independent risk factor for the occurrence of ACS in patients with essential hypertension. Among them, Fbg is the strongest independent risk factor for the occurrence of ACS in essential hypertension. FBG has the greatest influence on the occurrence of ACS in patients with essential hypertension. It provides a new direction for the prevention and treatment of ACS.
【作者单位】：山西省人民医院心内科;
【基金】：山西省社会发展基金(20120313018-8)
【分类号】：R541.4;R544.1

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