降钙素原对急性冠状动脉综合征患者行冠状动脉介入治疗后发生造影剂肾病的影响

发布时间：2018-03-22 04:38

本文选题：降钙素原　切入点：造影剂肾病　出处：《东南大学学报(医学版)》2017年03期 　论文类型：期刊论文

【摘要】：目的:探讨降钙素原(PCT)对急性冠状动脉综合征(ACS)患者行经皮冠状动脉介入治疗(PCI)后发生造影剂肾病(CIN)的影响。方法:选取260例在我院心内科行PCI治疗的ACS患者,根据入院时PCT水平分为高水平(PCT0.5 ng·ml-1)组和低水平(PCT≤0.5 ng·ml~(-1))组,探讨PCT水平对ACS患者PCI术后CIN发生率的影响及其因素。结果:260例患者共发生CIN 22例,发生率为8.5%。与低水平组(4.6%)相比,高水平组CIN发生率(12.3%)显著增加(P=0.026)。多因素Logistic回归分析显示,校正年龄、糖尿病、高脂血症、超敏C反应蛋白(hs-CRP)、估算肾小球滤过率(eGFR)、左心室射血分数(LVEF)及水化混杂因素后,PCT0.5 ng·ml~(-1)是发生CIN的独立危险因素(OR=1.6,95%CI为1.2~5.31,P=0.032)。结论:高水平的PCT可能促进ACS患者PCI术后CIN的发生。
[Abstract]:Objective: to investigate the effect of procalcitonin (PCT) on contrast-agent nephropathy (cin) after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). According to the PCT level on admission, the patients were divided into two groups: the high level group and the low level group. The effect of PCT level on the incidence of CIN after PCI operation in patients with ACS and its factors were investigated. Results 22 cases of CIN occurred in 20 cases of ACS, the incidence rate was 8.5%, compared with the low level group of 4.6%. The incidence of CIN in the high level group (12.3%) increased significantly. Multivariate Logistic regression analysis showed that age, diabetes, hyperlipidemia were corrected. Hs-CRP, estimation of glomerular filtration rate (GFR), left ventricular ejection fraction (LVEF) and PCT 0.5 ng / ml ~ (-1) after hydration were independent risk factors for the development of CIN. Conclusion: high level of PCT may promote the occurrence of CIN after PCI in ACS patients.
【作者单位】：东南大学附属中大医院心内科;
【基金】：国家自然科学基金资助项目(81370225)
【分类号】：R541.4;R692

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