血管内超声检测阿托伐他汀对兔动脉粥样硬化斑块的影响

发布时间：2018-03-22 15:28

本文选题：血管内超声　切入点：阿托伐他汀　出处：《山东大学学报(医学版)》2015年05期 　论文类型：期刊论文

【摘要】：目的采用血管内超声评价短期内不同剂量阿托伐他汀对动脉粥样硬化(AS)家兔模型斑块的影响。方法 30只新西兰大白兔随机分为对照组(n=7)、模型组(n=7)、阿托伐他汀低剂量组(n=8)和阿托伐他汀高剂量组(n=8)。对照组给予普通饲料喂养,其他各组均通过8周高脂喂养联合腹主动脉球囊损伤术建立AS模型。于第8周末行血管内超声检查。8周后,模型组,阿托伐他汀低、高剂量组继续高脂喂养,分别给予低、高剂量组兔不同剂量的阿托伐他汀干预2周。10周处死所有动物。抽取兔静脉血,测定血清血脂水平,应用ELISA法测定血清超敏C反应蛋白(hs-CRP)。并行血管内超声和病理组织学检查。结果对照组血脂水平明显低于其他各组(P0.05),阿托伐他汀低、高剂量两组血脂水平和血清hs-CRP水平明显低于模型组(P0.05),且高剂量组变化更加明显(P0.01)。血管内超声显示模型组的血管外弹力膜面积(EEMA)、斑块面积(PA)、管腔面积狭窄率(LAS%)明显大于低、高剂量组(P0.05),管腔面积(LA)差异无统计学意义(P0.05)。结论阿托伐他汀能够短时间内降低AS兔的血脂水平,并减少AS兔斑块的形成,且与药物剂量呈正相关。
[Abstract]:Objective to evaluate the effects of different doses of Atto vastatin on atherosclerotic atherosclerotic atherosclerotic plaque in rabbits by intravascular ultrasound. Methods Thirty New Zealand white rabbits were randomly divided into three groups: control group (n = 30), model group (n = 7) and Atto vastatin group (n = 30). The control group was fed with normal diet, the control group was fed with normal diet, and the control group with high dose of Atto vastatin. Other groups were treated with high-fat feeding combined with abdominal aortic balloon injury for 8 weeks to establish as model. After 8 weeks of intravascular ultrasound examination, the model group, Atto vastatin was low, and the high dose group continued to be fed with high fat, respectively. The rabbits in the high dose group were killed by different doses of Atto vastatin for 2 weeks and 10 weeks. The venous blood was taken from the rabbits and the serum lipid level was measured. The serum hypersensitive C-reactive protein hs-CRP was determined by ELISA method. Intravascular ultrasound and histopathology were performed. Results the serum lipid level in the control group was significantly lower than that in the other groups (P 0.05), and Atto vastatin was low. The plasma lipid level and serum hs-CRP level in the high dose group were significantly lower than those in the model group, and the changes in the high dose group were more obvious than those in the model group. The area of the extravascular elastic membrane, plaque area, lumen area and lumen area stenosis rate in the model group were significantly higher than those in the model group. There was no significant difference in lumen area between high dose group and P0.05.Conclusion Atto vastatin can reduce lipid level and plaque formation in as rabbits in a short time, and has positive correlation with drug dose.
【作者单位】：山东大学医学院;山东大学附属济南市中心医院心内科;山东大学附属济南市中心医院供应科;
【基金】：国家自然科学基金(81170087) 济南市企业自主创新计划(201003112)
【分类号】：R543.5

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