丹蒌片治疗冠心病稳定型心绞痛（痰瘀互结证）运动平板试验分析及心绞痛症状的疗效观察

发布时间：2018-03-25 23:01

本文选题：丹蒌片　切入点：冠心病稳定型心绞痛　出处：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的本研究是对丹蒌片治疗冠心病稳定型心绞痛,中医分型为痰瘀互结证者,观察患者运动平板试验改善情况以及心绞痛症状积分变化的疗效比较,结合临床证治,进而验证丹蒌片对于本病的疗效及安全性。方法本临床观察将符合冠心病稳定型心绞痛的诊断标准,分型为痰瘀互结证的60例患者随机分为45例治疗组和15例阳性药物对照组,疗程共8周。疗程完成后观察运动试验总时间、Duke评分等运动耐量指标的改变、心绞痛症状积分以及疗效的变化、中医证候积分的变化以及对用药前后肝肾功能指标的检测。结果1.平板试验总运动时间、Duke评分等运动耐量指标的改变:两组用药后差异比较,△P0.05具有统计学意义,治疗组运动耐量改变优于对照组。2.心绞痛症状积分及疗效改善:两组间用药后比较差异,△P0.05有统计学意义,用药后治疗组疗效改变明显。3.中医证候积分及疗效变化:比较用药后组间差异,△P0.05有统计学意义,用药后治疗组中医证候疗效优于对照组。4.肝肾功能检测:比较两组用药前差异P0.05无统计学意义,用药后两组间比较差异P0.05无统计学意义。结论1.丹蒌片可以有效改善冠心病稳定型心绞痛(痰瘀互结证)患者运动平板试验总运动时间以及Duke评分;2.丹蒌片可以有效改善冠心病稳定型心绞痛(痰瘀互结证)患者的心绞痛症状以及中医证候表现;3.丹蒌片在试验过程中对肝肾功能检测未见异常,没有不良事件发生,具有安全性。
[Abstract]:Objective to study the therapeutic effect of Danlou tablet on stable angina pectoris of coronary heart disease, which was classified as syndromes of phlegm and blood stasis, to observe the improvement of exercise treadmill test and the change of symptom integral of angina pectoris, and to combine with clinical treatment. Methods 60 patients with stable angina pectoris were randomly divided into treatment group (45 cases) and positive drug control group (15 cases). After the course of treatment was completed, the changes of exercise tolerance index, angina symptom score and curative effect were observed, such as the total time of exercise test and Duke's score. Changes of TCM syndromes integral and the detection of liver and kidney function before and after medication. Results 1. Changes of exercise tolerance indexes such as total exercise time and Duke score of treadmill test: the difference between the two groups was statistically significant (P0.05). The change of exercise tolerance in the treatment group was better than that in the control group .2.The symptom score and curative effect of angina pectoris were improved: the difference between the two groups was statistically significant (P0.05). After treatment, the curative effect of the treatment group changed significantly .3.The integral of TCM syndrome and the change of curative effect: the difference between the groups after medication was statistically significant (P0.05). The therapeutic effect of TCM syndrome in the treatment group was better than that in the control group. 4. The detection of liver and kidney function: there was no significant difference between the two groups before treatment (P0.05). Conclusion: 1. Danlou tablet can effectively improve the total exercise time and Duke score of the patients with stable angina pectoris of coronary heart disease (phlegm and blood stasis syndromes). 2. Danlou tablet can improve the exercise time of the patients with stable angina pectoris of coronary heart disease (phlegm and blood stasis syndromes). The symptoms of angina pectoris and TCM syndromes in patients with stable angina pectoris of coronary heart disease (phlegm and blood stasis syndromes) were effectively improved. No adverse events occur and are safe.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.4

【相似文献】