两种剂量阿托伐他汀对PCI术后患者炎性因子水平及MACE的影响

发布时间：2018-03-26 06:26

本文选题：冠状动脉疾病　切入点：经皮冠状动脉介入术　出处：《山东医药》2017年17期

【摘要】：目的探讨两种剂量(20、40 mg)阿托伐他汀对经皮冠状动脉介入术(PCI)后患者超敏C反应蛋白(hsCRP)、脂联素(APN)、网膜素1(OE-1)等炎性因子水平及主要不良心血管事件(MACE)的影响。方法选取行PCI术患者111例,随机分为A、B组,分别于入院时服用阿托伐他汀40、20 mg/d。检测入院(未服药)时、术后3 d、术后3个月的血脂及hs-CRP、APN、OE-1;随访3个月统计药物不良反应及随访1年MACE。结果术后3个月两组TC、TG水平均较入院前降低(P均0.05),且A组低于B组(P均0.05)。术后3 d、3个月两组血清hs-CRP水平均较入院前降低,血清APN、OE-1水平均较入院前升高(P均0.05)。且术后3个月A组血清hs-CRP水平低于B组,血清APN、OE-1水平高于B组(P均0.05)。两组不良反应发生率比较差异无统计学意义(P0.05),MACE发生率比较差异有统计学意义(P0.05)。结论 20、40 mg阿托伐他汀均能降低PCI术后患者血清hsCRP水平,升高APN、OE-1水平,降低MACE发生率,但40 mg阿托伐他汀效果更佳。
[Abstract]:Objective to investigate the effects of two doses of 2040 mg) Atto vastatin on the levels of inflammatory factors, such as hsCRPU, adiponectin (APNN) and omental hormone (1OOE-1), after percutaneous coronary intervention (PCI) in patients with PCI. Methods the main adverse cardiovascular events were selected. PCI was performed in 111 patients. They were randomly divided into two groups: group A (group B), who were treated with Atto vastatin 4020 mg / d on admission. Blood lipids and hs-CRP APNOE-1 were measured 3 days after operation, adverse drug reactions and 1 year MACE-1 were recorded after 3 months follow-up. Results the levels of TCN TG in both groups were lower than those before admission (P 0.05), and in group A were lower than those in group B (P 0.05) 3 days after operation, 3 patients in group A were less than those in group B at 3 days after operation, 3 patients in group A were lower than those in group B at 3 days after operation. The serum hs-CRP levels in the two groups were lower than those before admission. The serum levels of APNN, OE-1 and hs-CRP in group A were significantly lower than those in group B 3 months after admission (P < 0.05), and the level of serum hs-CRP in group A was lower than that in group B 3 months after operation. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion 2040 mg Atto vastatin can decrease the level of serum hsCRP and increase the level of APNOE-1 in patients after PCI. The incidence of MACE was reduced, but 40 mg Atto vastatin was more effective.
【作者单位】：河北医科大学研究生学院;唐山工人医院;
【分类号】：R541.4

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