野百合碱性肺动脉高压大鼠右心功能分析

发布时间：2018-03-28 16:16

本文选题：肺动脉高压　切入点：大鼠　出处：《中国实验动物学报》2017年05期

【摘要】：目的研究肺动脉压力演变和右心室功能演变之间的关系。方法将MCT诱导的4组肺动脉高压(pulmonary artery hypertension,PAH)模型组(每小组12只),分别在第1、2、3、4周应用右心导管测量肺动脉压力,MRI右心功能动态检测,观察肺动脉压力和MRI参数演变关系。比较对照组、PAH模型组各组间的相关各参数差异。采用SPSS 17.0统计软件,应用Pearson相关性分析,评价右心室射血分数,右室舒张末期容积,右室收缩末期容积分别与平均肺动脉压的相关性,组间比较采用完全随机分组的t检验,P0.05为差异有显著性。结果注射野百合碱后1~4周,48只模型组大鼠的右心室射血分数、右心室舒张及收缩末期容积与平均肺动脉压有很好的相关性(分别为r_(RVEF)=-0.823,r_(RVEDV)=0.732,r_(RVESV)=0.803)。注射野百合碱前两周,野百合碱组大鼠的平均肺动脉压、右心室射血分数、右室舒张末期和收缩末期容积与对照组比较差异无显著性(P0.05)。3~4周后,以上各参数与对照组比较差异有显著性(P0.05)。结论随着大鼠的肺动脉压增高,右心室射血分数逐渐降低,右心室舒张末期及收缩末期容积逐渐增加。对于大鼠慢性肺动脉高压模型的监测,MRI可以准确快速测量各项参数变化,右心室舒张末及收缩末期容积、射血分数等参数是提示肺动脉高压的敏感参数。
[Abstract]:Objective to study the relationship between pulmonary artery pressure and right ventricular function in the evolution of evolution. Methods 4 MCT induced pulmonary hypertension group (pulmonary artery, hypertension, PAH) model group (12 in each group), respectively in the first week of 1,2,3,4 applied to the right measurement of pulmonary artery catheter pressure, right ventricular function MRI dynamic detection, observation of lung arterial pressure and MRI parameters evolution relationship. Compared with the control group, PAH model group differences between each group of relevant parameters. Using SPSS 17 statistical software, using Pearson correlation analysis, evaluation of right ventricular ejection fraction, left ventricular end diastolic volume, right ventricular end systolic volume were correlated with mean pulmonary arterial pressure, comparison between groups using t test completely randomized, P0.05 had significant difference. The results of 1~4 weeks after MCT injection, 48 rats of the right ventricular ejection fraction, diastolic and systolic volume and mean pulmonary right ventricle There is a good correlation between arterial blood pressure (r_ (RVEF) =-0.823, r_ (RVEDV) =0.732, r_ (RVESV) =0.803). Two weeks before the injection of monocrotaline, pulmonary arterial mean monocrotaline rats pressure, right ventricular ejection fraction, left ventricular end diastolic and end systolic volume and the control group had no significant difference (P0.05) after.3~4 weeks, there were significant differences in the above parameters and the control group (P0.05). Conclusion with the rat pulmonary artery pressure increased, the right ventricular ejection fraction decreased gradually, right ventricular end diastolic and end systolic volume increased gradually. In the monitoring of chronic pulmonary arterial hypertension rat model, MRI can change quickly and accurately measure the parameters of right ventricular end diastolic and end systolic volume, ejection fraction and other parameters are sensitive parameters of pulmonary hypertension.

【作者单位】：首都医科大学宣武医院放射科;
【基金】：北京市自然科学基金(No.7163217)
【分类号】：R544.1

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