自身免疫性溶血性贫血患者ABO血型鉴定及抗体筛查

发布时间：2018-03-28 23:13

本文选题：自身免疫性溶血性贫血(AIHA)　切入点：ABO血型　出处：《中国输血杂志》2017年08期

【摘要】：目的探讨自身免疫性溶血性贫血(AIHA)患者的ABO血型鉴定及抗体筛查方案。方法 2015年1月-2016年12月46例AIHA患者试管法进行ABO正反定型,直接抗球蛋白试验及间接抗球蛋白试验判定自身免疫性溶血性贫血,氯喹放散或自身红细胞吸收自身抗体后,进行不规则抗体筛查及抗体特异性鉴定。结果 46例AIHA患者DAT均阳性,IAT阳性患者20例。在20例IAT阳性患者,抗筛阳性者6例(30%),抗体特异性鉴定:抗-E 4例,抗-c 1例,抗-c E 1例。此外,ABO正反定型不一致者18例,IAT阳性者11例,28例ABO血型未受干扰者中,IAT阳性者9例,间抗阳性者比间抗阴性者更容易发生ABO血型鉴定困难,差异有统计学意义(χ2=46.00,P0.001)。结论正确判定AIHA患者ABO血型及抗体筛查,选择合适血液输注,有利于提高临床输血安全性。
[Abstract]:Objective to investigate the ABO blood group identification and antibody screening in patients with autoimmune hemolytic anemia (AHA). Methods 46 patients with AIHA from January 2015 to December 2016 were treated with positive and negative ABO typing. Direct antiglobulin test and indirect antiglobulin test were used to determine autoimmune hemolytic anemia, chloroquine elution or absorption of autoantibodies by autologous erythrocytes. Results there were 20 cases of DAT positive in 46 cases of AIHA, 6 cases of anti-sieve positive, 4 cases of anti-E, 1 case of anti-c. In addition, among 18 cases with positive or negative ABO blood group, 11 cases were positive for ABO blood type, 9 cases were positive for ABO blood group, and 9 cases were more likely to have difficulty in identifying ABO blood group than those with negative anti ABO blood group. The difference was statistically significant (蠂 2: 46.00 P 0.001). Conclusion it is helpful to determine the ABO blood type and antibody screening of AIHA patients and to select the appropriate blood transfusion to improve the safety of clinical blood transfusion.
【作者单位】：洛阳市中心血站;南方医科大学南方医院;
【分类号】：R457.11;R556

【相似文献】