HCY与冠心

发布时间：2018-03-29 23:15

本文选题：高血压　切入点：冠心病　出处：《桂林医学院》2013年硕士论文

【摘要】：目的：揭示同型半胱氨酸与高血压、冠心病之间的关联性，指导对相关疾病的预防及治疗，降低其发病率和死亡率。方法：选择符合诊断标准的冠心病60例（冠心病组），高血压病120例（高血压病组），体检健康者20例（对照组）。（1）冠心病组按主要冠脉狭窄支数分为单支组、双支组、多支组。（2）冠心病组按冠脉病变狭窄程度分为轻度组、重度组。（3）冠心病组按不同类型分为稳定性组，不稳定组，急性心梗组，陈旧性心梗组。（4）依照血浆HCY值将高血压分为A组(Hcy＜10mol/L)；B组(Hcy＜15mol/L{10-15mol/L})；C组(Hcy＜20mol/L{15-20mol/L})；D组(Hcy≥20mol/L)。根据血浆HCY值进行比较，，并得出结果。结果：（1）相比多支组较单支组、双支组；双支组较单支组HCY均出现明显升高，具显著统计学差异(p＜0.01；p＜0.05）。（2）轻度组、重度组血浆Hcy水平较对照组；重度组较轻度组出现显著升高，具显著统计学差异(p＜0.01；p＜0.05）。（3）不稳定型心绞痛、急性心肌梗塞组血浆Hcy水平明显高于稳定型心绞痛组与陈旧性心肌梗塞组，差异有显著性（p＜0.01）。不稳定型心绞痛组与急性心肌梗塞组相比较，均无显著统计学差异（p＞0.05）。（4）高血压1级组，2级组，3级组血浆Hcy水平较对照组；相比2级组、3级组较1级组；3级组较2级组均有明显提高，具有统计学意义（p0.05）。（5）心血管事件发生率与血浆Hcy关系密切，血浆同型半胱氨酸越高，心血管事件发生率越高。 A组与B组、C组、D组间；B组与C组、D组间；C组与D组间出现显著差异性（p0.01）。结论：（1）冠心病血管病变支数和狭窄程度与血浆Hcy水平具高度相关性，病变程度越重、病变支数越多，血浆Hcy水平越高。（2）血浆Hcy水平提示对不同冠心病类型的诊断、病情及预后提供一定的临床意义。（3）高血压与血浆Hcy具有协同作用，二者同时存在时，可提高患者罹患心血管疾病的危险性。
[Abstract]:Objective: to explore the relationship between homocysteine and hypertension, coronary heart disease, and to guide the prevention and treatment of related diseases. Methods: 60 cases of coronary heart disease (CHD group), 120 cases of hypertension (hypertension group) and 20 healthy persons (control group) were selected according to the main coronary artery stenosis. The number of branches is divided into one branch group, The coronary heart disease group was divided into mild group and severe group according to the degree of coronary artery stenosis. The coronary heart disease group was divided into stable group, unstable group, acute myocardial infarction group according to different types, the coronary artery disease group was divided into stable group, unstable group and acute myocardial infarction group according to the degree of coronary artery stenosis. According to the plasma HCY value, hypertension was divided into two groups: group A < 15mol/L < 10 mol / L Hcy < 15mol/L {10-15mol/L} and group C < 20mol/L {15-20mol/L} Hcy > 20 mol / L, and the results were compared according to the plasma HCY value, and the results were as follows: compared with the single branch group and the double branch group; The level of plasma Hcy in severe group was significantly higher than that in control group (P < 0.01, P < 0.05, P < 0.05, P < 0.01, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05), and the level of plasma Hcy in severe group was significantly higher than that in control group (P < 0.01, P < 0.05, P < 0.05, P < 0.05, P < 0.05, P < 0.05). The plasma Hcy level in acute myocardial infarction group was significantly higher than that in stable angina pectoris group and old myocardial infarction group (P < 0.01). There was no significant difference between unstable angina pectoris group and acute myocardial infarction group. The incidence of cardiovascular events was significantly higher in grade 2 group than in grade 1 group 3 group than in grade 2 group. There was a statistically significant relationship between the incidence of cardiovascular events and plasma Hcy, and the plasma homocysteine level was higher. The higher the incidence of cardiovascular events was, the higher the incidence of cardiovascular events was. There was a significant difference between group A and group B and group C and between group C and group D. conclusion there is a high correlation between the number of branches and the degree of stenosis of coronary artery disease and the level of plasma Hcy. The more serious the lesion, the more the number of diseased branches, the higher the plasma Hcy level. 2) the higher the plasma Hcy level, the higher the clinical significance for the diagnosis, condition and prognosis of different types of coronary heart disease.) Hypertension has synergistic effect with plasma Hcy. At the same time, it can increase the risk of cardiovascular disease.
【学位授予单位】：桂林医学院
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R544.1;R541.4

【相似文献】