19例心肌淀粉样变性患者的临床特点及预后分析

发布时间：2018-04-02 00:31

本文选题：心肌病　切入点：心肌淀粉样变性　出处：《临床心血管病杂志》2017年02期

【摘要】：目的:探讨心肌淀粉样变性(CA)患者的临床特征和预后。方法:回顾性分析19例CA患者的临床资料,对患者的生存影响因素进行相关性和Cox回归分析。结果:19例患者均出现心功能不全表现;肢体导联低电压10例;心脏核磁共振显像心肌呈不同程度延迟强化11例;就诊前有晕厥病史3例;19例患者中死亡9例,平均随访时间(24.2±4.5)个月,1年生存率为67.7%,2年生存率为56.4%,中位生存期为25.1个月。相关性分析表明,患者生存时间与入院时氨基末端B型脑钠肽前体(NT-proBNP)水平、晕厥病史之间存在负相关(r=-0.635,P=0.013;r=-0.632,P=0.002);单因素Cox回归分析,入院时NT-proBNP水平为CA预后的预测指标(P0.05)。结论:CA预后不佳,生存时间与入院时NT-proBNP水平、晕厥病史密切相关,入院时NTproBNP水平是CA患者预后的预测指标。
[Abstract]:Objective: to investigate the clinical features and prognosis of patients with myocardial amyloidosis (CAA). Methods: the clinical data of 19 patients with CA were analyzed retrospectively. The correlation of survival factors and Cox regression analysis were carried out. Results all 19 cases had cardiac insufficiency, 10 cases had low voltage in limb lead, 11 cases had delayed enhancement of cardiac muscle in different degree by magnetic resonance imaging (MRI), 10 cases had low voltage in limb lead, 11 cases had delayed enhancement of myocardium in different degree by nuclear magnetic resonance imaging. Of the 19 patients with history of syncope before treatment, 9 died, with an average follow-up time of 24.2 卤4.5 months. The 1-year survival rate was 67.7, the 2-year survival rate was 56.4 and the median survival time was 25.1 months. There was a negative correlation between survival time and NT-proBNPs at admission and history of syncope. Univariate Cox regression analysis showed that NT-proBNP level at admission was a predictor of prognosis of CA. The survival time was closely related to the NT-proBNP level at admission and the history of syncope. The NTproBNP level at admission was a predictor of the prognosis of CA patients.
【作者单位】：电子科技大学附属四川省人民医院心内科;成都医学院体温与炎症四川省高校重点实验室;
【分类号】：R542.2

【相似文献】