模拟热浪期间突然强降温天气对高血压大鼠心血管系统影响的实验研究

发布时间：2018-04-02 02:13

  本文选题：热浪　切入点：强降温　出处：《科学技术与工程》2017年03期

【摘要】：通过模拟热浪期间突然强降温天气对高血压大鼠影响的实验研究,探讨热浪期间突然强降温对高血压大鼠心血管疾病的影响机理。应用TME1880气象环境模拟箱模拟了南京2006年6月19日5时至22日11时高温热浪期间突然强降温天气过程,将24只高血压大鼠随机分为实验组(包括热浪组、降温组和复温组)和对照组,每组各6只大鼠。把实验组放入模拟箱内,使其受热浪期间突然强降温天气过程影响,分别在模拟热浪期间突然强降温天气过程55、59和75 h时,先后取出热浪组、降温组和复温组监测基本生理指标;并采用断头采血和摘取心尖,测量各组高血压大鼠的热应激因子(HSP60、SOD、s ICSM-1、HIF-1α)、冷应激因子(NE、EPI、ANGⅡ)、血管收缩因子(ET-1、NO)以及心血管的危险因素(TC、TG、HDL-C、LDL-C和Tn-T)生化指标的含量。结果表明受高温热浪的影响,高血压大鼠的热应激因子除SOD含量明显下降以外其他热应激因子含量均明显增加,冷应激因子均明显下降,血管收缩因子ET-1下降而NO上升,心脑血管危险因素除TG上升以外其余因子均有不同程度的下降。热浪期间突然强降温可导致高血压大鼠热应激因子除SOD上升以外其余均下降,冷应激因子全部上升,血管收缩因子ET-1上升而NO下降,心血管危险因素均上升。通过分析可知,热浪可使得高血压大鼠动脉粥样硬化加剧,热浪期间突然强降温使得NE和ANGⅡ含量明显增加,加剧血压升高。受降温的影响Tn-T明显增多,说明突然的强降温冷刺激导致的血管收缩导致了心肌缺血,加上血脂四项的升高使得高血压大鼠心血管疾病进一步加重。初步探讨了热浪期间突然强降温天气对高血压大鼠心血管疾病的影响。
[Abstract]:By simulating the effect of sudden and intense cooling weather during heat wave on hypertensive rats, the mechanism of the effect of sudden strong cooling during heat wave on cardiovascular disease in hypertensive rats was investigated.The TME1880 meteorological environment simulation box was used to simulate the sudden strong cooling weather process in Nanjing during the high temperature heat wave from 5: 00 to 11:00 on June 19, 2006. Twenty-four hypertensive rats were randomly divided into experimental group (including heat wave group).Cooling group and rewarming group) and control group, 6 rats in each group.The experimental group was put into the simulation box and affected by the sudden strong cooling weather process during the heat wave. The heat wave group was taken out at 5559 h and 75 h, respectively, during the simulated heat wave period.The basic physiological indexes were monitored in hypothermia group and rewarming group.The contents of heat stress factor (HSP60), ICSM-1 (HIF-1 伪), cold stress factor (NEEPIANG 鈪，

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