探究中西药联合应用治疗慢性稳定性心绞痛的优势

发布时间：2018-04-03 17:47

  本文选题：冠心病心绞痛　切入点：三七粉　出处：《延边大学》2017年硕士论文

【摘要】：目的:通过观察联合应用三七粉与硝酸甘油治疗慢性稳定性心绞痛的临床疗效,从而为临床提供试验依据。方法:选取自2015年1月至2017年1月期间就诊延边大学附属医院门诊及住院治疗的60例,既符合慢性稳定性心绞痛的西医诊断标准,又符合中医辨证标准的患者。将他们根据看病先后分为对照组和治疗组,每组各30例。年龄和性别无显著性差别,生理状态基本相同。治疗组给予三七粉(每次3g,每日2次)和硝酸甘油(0.5mg,必要时舌下含服)治疗;对照组单独给予硝酸甘油(0.5mg,必要时舌下含服)治疗。20天为一个疗程。经过3个疗程治疗后对比分析两组的中医主要证候积分变化、心绞痛症状变化情况、硝酸甘油停减率、心电图的变化,并观察肝肾功能等安全指标。结果:1.心绞痛发作时间的比较:治疗组中心绞痛持续发作时间比对照组短,P0.05,统计学有差异性。2.硝酸甘油停减率的情况比较分析:治疗后,治疗组中患者的减停率明显优于对照组,P0.05,统计学有差异性。说明治疗组中患者对硝酸甘油的使用依赖性没有对照组强。3.肝肾功能变化:治疗组与对照组在治疗后均无肝肾功能检验异常表现,由此可见本治疗方案无严重毒副作用和不良反应。结论:三七粉与硝酸甘油联用治疗慢性稳定性心绞痛,在改善心绞痛发作持续时间、硝酸甘油减停率等方面有显著疗效,同时在提高临床综合症状的疗效等方面疗效均大于单独应用硝酸甘油治疗的对照组。
[Abstract]:Objective: to observe the clinical effect of combined use of Notoginseng powder and nitroglycerin in the treatment of chronic stable angina pectoris.Methods: from January 2015 to January 2017, 60 cases of outpatient and inpatient treatment in affiliated Hospital of Yanbian University were selected. The patients not only accord with the diagnostic criteria of western medicine for chronic stable angina pectoris, but also accord with the standard of TCM syndrome differentiation.They were divided into control group and treatment group, 30 cases in each group.There was no significant difference in age and sex, and the physiological state was basically the same.The treatment group was treated with Sanqi powder (3 g, twice a day) and nitroglycerin (0.5 mg, if necessary), while the control group was treated with nitroglycerin alone (0.5 mg, sublingual when necessary) for 20 days as a course of treatment.After three courses of treatment, the changes of TCM main syndromes, angina pectoris symptom, nitroglycerin reduction rate, electrocardiogram and other safety indexes were compared and analyzed.The result is 1: 1.Comparison of angina pectoris attack time: the duration of sustained angina attack in the treatment group was shorter than that in the control group (P 0.05).Comparison and analysis of the stopping and decreasing rate of nitroglycerin: after treatment, the stopping rate of the patients in the treatment group was obviously better than that in the control group (P 0.05), there was statistical difference.It showed that the patients in the treatment group were less dependent on nitroglycerin than the control group. 3. 3.The changes of liver and kidney function: there were no abnormal manifestations of liver and kidney function test in the treatment group and control group after treatment, so there were no serious side effects and adverse reactions.Conclusion: the treatment of chronic stable angina pectoris with panax notoginseng powder combined with nitroglycerin has a remarkable effect on improving the duration of angina pectoris attack and decreasing stop rate of nitroglycerin.At the same time, the therapeutic effect of nitroglycerin alone was higher than that of the control group.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.4
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本文编号：1706253