辛伐他汀联合依那普利对老年高血压患者骨质疏松治疗的效果观察

发布时间：2018-04-05 21:04

本文选题：高血压　切入点：骨质疏松　出处：《中国骨质疏松杂志》2017年10期

【摘要】：目的对比研究老年高血压并骨质疏松患者口服依那普利联合辛伐他汀对骨密度及骨代谢指标的效果。方法选择2013年7月~2015年9月我院老年高血压并骨质疏松患者126例为研究对象,随机、双盲分为治疗组(n=63)和对照组(n=63)。治疗组患者口服依那普利+辛伐他汀,对照组口服依那普利。两组观察6个月,测定治疗前及治疗后6个月的血清骨钙素(OC)、血清Ⅰ型胶原C末端肽(s-CTX)、血清骨源性碱性磷酸酶(BAP)、血清抗酒石酸酸性磷酸酶-5b(TRACP-5b)和骨密度值[腰椎正位、股骨颈、前臂、股骨粗隆]的水平。结果两组各骨密度及骨代谢指标参数基线值比较,差异无统计学意义(P0.05)。治疗后,两组OC、BAP及腰椎正位、股骨颈、前臂、股骨粗隆的BMD水平显著增大,且s-CTX、TRACP-5b水平显著降低(P0.05),而治疗组治疗后OC、BAP、s-CTX、TRACP-5b及腰椎正位、股骨颈、前臂、股骨粗隆的BMD水平改变显著优于对照组(P0.05)。结论老年高血压并骨质疏松患者给予口服依那普利和辛伐他汀治疗后6个月,较单纯口服依那普利骨密度值显著上升。
[Abstract]:Objective to compare the effects of oral enalapril and simvastatin on bone mineral density and bone metabolism in elderly patients with hypertension and osteoporosis.Methods A total of 126 elderly patients with hypertension and osteoporosis from July 2013 to September 2015 were randomly divided into two groups: treatment group (n = 63) and control group (n = 63).Patients in the treatment group were treated with enalapril simvastatin and those in the control group were treated with enalapril.Level of forearm, trochanter of femur.Results there was no significant difference in bone mineral density and bone metabolism parameters between the two groups (P 0.05).After treatment, the levels of BMD in the lumbar vertebrae, neck of femur, forearm and trochanter of femur increased significantly in both groups, and the levels of s-CTXT TRACP-5b decreased significantly (P 0.05), while in the treatment group, the levels of OCAP BAPs-CTX TX TRACP-5b and lumbar vertebrae, femoral neck, forearm, OCAPs-CTX + TRACP-5b were significantly decreased after treatment.The change of BMD level in trochanter of femur was significantly better than that in control group (P 0.05).Conclusion the bone mineral density (BMD) of elderly patients with hypertension and osteoporosis increased significantly 6 months after oral enalapril and simvastatin treatment.
【作者单位】：新疆石河子大学医学院第一附属医院骨二科;新疆石河子大学医学院第一附属医院药剂科;
【分类号】：R544.1;R580

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