甲状旁腺素在高血压发病中的作用

发布时间：2018-04-08 16:43

本文选题：甲状旁腺素　切入点：高血压　出处：《中国老年学杂志》2017年04期

【摘要】：目的探讨甲状旁腺素(iPTH)及其与水盐代谢调节因素相互作用在高血压发病中的作用及机制。方法切除小鼠的甲状旁腺,检测小鼠24 h血压、白天血压和夜间血压的变化以及对小鼠血压节律和血压变异率的影响;给小鼠注射iPTH,检测小鼠体内醛固酮的含量以及血压的变化。结果敲除小鼠的甲状旁腺后,小鼠24 h、白天和夜间的收缩压和舒张压都显著低于对照组;iPTH敲除小鼠的血压变异率低于未敲除甲状旁腺的小鼠(P0.05);甲状旁腺敲除小鼠的白天和夜间血压出现峰值的时间与对照组有所改变。对照组小鼠白天血压峰值出现在上午9点,夜间血压峰值为20点,夜间血压的峰值高于白天的峰值。甲状旁腺敲除小鼠的白天血压峰值出现在上午9点,夜间血压峰值时间为24点,夜间血压的峰值高于白天的峰值;给小鼠注射80μg/kg的iPTH后,醛固酮含量与对照组比较显著上升,血压比对照组显著升高(P0.05)。结论 iPTH能降低血压,且能与醛固酮相互作用对血压进行调节。
[Abstract]:Objective to investigate the role and mechanism of parathyroid hormone (PTH) and its interaction with the regulating factors of water and salt metabolism in the pathogenesis of hypertension.Methods the parathyroid gland of mice was excised and the changes of blood pressure at 24 hours, daytime and night, and the blood pressure rhythm and blood pressure variation rate were detected.The aldosterone content and blood pressure were measured by injecting iPTHs into mice.Results after knockout the parathyroid gland of the mouse,At 24 h, systolic blood pressure and diastolic blood pressure in mice were significantly lower than those in control group iPTH knockout mice (P 0.05), and peak blood pressure was observed in parathyroid knockout mice during day and night.The time changed with the control group.In the control group, the peak of daytime blood pressure appeared at 9 o'clock in the morning, the peak of blood pressure at night was 20:00, and the peak value of blood pressure at night was higher than that in the day.The peak of daytime blood pressure of parathyroid knockout mice appeared at 9: 00 in the morning, the peak time of nocturnal blood pressure was 24:00, the peak value of nocturnal blood pressure was higher than that of daytime, the aldosterone content of mice injected with 80 渭 g/kg iPTH increased significantly compared with the control group.The blood pressure was significantly higher than that of the control group (P 0.05).Conclusion iPTH can lower blood pressure and regulate blood pressure by aldosterone interaction.
【作者单位】：昆明医科大学第二附属医院心内科三病区;昆明医科大学第二附属医院放射介入治疗室;
【基金】：云南省自然科学基金(No.2013FZ284) 云南省教育厅基金项目(2013C241)
【分类号】：R544.1

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