药物洗脱支架对冠状动脉临界病变合并易损斑块干预的临床预后

发布时间：2018-04-09 20:10

本文选题：药物洗脱支架　切入点：临界病变　出处：《实用医学杂志》2017年17期

【摘要】：目的探讨药物洗脱支架联合标准药物治疗与单纯标准药物治疗对冠状动脉临界病变合并易损斑块干预的临床预后研究。方法连续入选2011年7月至2016年1月住院的冠状动脉临界病变合并易损斑块患者327例,临界病变指冠脉造影50%冠脉直径狭窄70%,64排冠脉CT检测易损斑块。随机分为药物洗脱支架联合标准药物治疗组(支架组)与单纯标准药物治疗组(药物组),随访1年内主要心脏不良事件MACE(死亡、心梗、靶血管再次血运重建)。结果支架组成功随访160例,5例出现MACE;药物组成功随访160例,16例出现MACE,支架组较药物组MACE减少,差异具有统计学意义(3.13%vs.10%,log-rank检验χ~2=6.62,P=0.01);支架组较药物组死亡、心梗减少,差异具有统计学意义(1.25%vs.5.63%,log-rank检验χ~2=4.61,P=0.03)。结论对于冠状动脉临界病变合并易损斑块的处理策略,药物洗脱支架联合标准药物治疗较单纯标准药物治疗可以减少MACE。
[Abstract]:Objective to investigate the clinical prognosis of coronary artery stenosis with vulnerable plaque intervention in drug eluting stent combined with standard drug treatment and simple drug standard. Methods a total of 327 consecutive patients with coronary boderline lesions from July 2011 to January 2016 were plaque cases, borderline lesion of coronary angiography coronary artery diameter stenosis 50% to 70%, 64 rows of detection of vulnerable coronary CT plaques were randomly divided into the drug eluting stent combined with standard drug treatment group (stent group) and simple standard drug treatment group (drug group), 1 years follow-up of major cardiac adverse events (death, myocardial infarction, MACE target vessel revascularization). Results 160 cases of stents were successfully followed up, 5 cases of drug MACE; successful follow-up of 160 cases, 16 cases with MACE stent group than the drug group MACE decreased, the difference was statistically significant (3.13%vs.10%, 6.62 x ~2= log-rank test, P=0.01); a support group The medicine group of death, myocardial infarction decreased, the difference was statistically significant (1.25%vs.5.63%, log-rank test, X ~2=4.61, P=0.03). Conclusion the treatment strategy for coronary borderline lesions with vulnerable plaques, stent combined with standard drug treatment compared with standard drug therapy can reduce MACE. drug eluting

【作者单位】：广西壮族自治区南溪山医院心内科;广西壮族自治区南溪山医院影像科;广西壮族自治区南溪山医院检验科;
【基金】：广西医疗卫生重点科研课题(编号:重2011020)
【分类号】：R541.4

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