银杏酮酯分散片对冠心病稳定型心绞痛（心血瘀阻证）心绞痛症状及中医证候的疗效观察

发布时间：2018-04-10 13:44

本文选题：银杏酮酯分散片 + 冠心病稳定型心绞痛　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:评价银杏酮酯分散片在冠心病稳定型心绞痛(心血瘀阻证)的治疗中对改善心绞痛症状、中医证候、心电图以及硝酸甘油停减率等方面的有效性及安全性。方法:试验观察运用随机、双盲、阳性药对照的方法,选择2016年3月到2016年11月在黑龙江中医药大学附属第一医院心内三就诊患者,诊断符合入组标准并且自愿同意进行试验观察的60例心脏病患者。随机的将患者分为治疗组(口服银杏酮酯分散片,1片/次,每日3次,口服金纳多模拟剂,1片/次,每日3次)32例和对照组(口服金纳多,1片/次,每日3次,口服银杏酮酯分散片模拟剂,1片/次,每日3次)28例,用药8W±2d,结束后观察银杏酮酯分散片治疗胸痹心痛(心血瘀阻证)在中医证候、心绞痛症状、心电图以及硝酸甘油停减率方面的疗效。结果:1.心绞痛症状方面,对照组的总有效率达67.86%,治疗组的总有效率达93.75%,两组患者有效率经秩和检验P0.05,有统计学差异。2.在中医证候评分方面,治疗组和对照组患者治疗前后中医证候评分变化均有显著性差异(P0.05),中医证候疗效方面,对照组的总有效率达71.43%,治疗组的总有效率达93.75%,两组患者中医证候疗效经秩和检验P0.05,存在统计学差异。3.在硝酸甘油停减率方面,对照组的总有效率达71.43%,治疗组的有效率达93.75%,两组患者经秩和检验P0.05,有统计学差异。4.在心绞痛发作次数方面,治疗后治疗组与对照组经配对t检验P0.05,差异有统计学意义。在心绞痛发作持续时间方面,治疗组和对照组治疗后心绞痛发作持续时间均减少,前后进行配对t检验P0.05,差异具有统计学意义。5.在心电图改善方面,对照组的总有效率达35.71%,治疗组的有效率达50%,两组患者有效率经秩和检验P0.05,差异不具有统计学意义。6.两组肝、肾功指标经配对t检验比较,治疗组和对照组治疗前后均无显著差异(P0.05)。结论:1.银杏酮酯分散片具有改善冠心病稳定型心绞痛(心血瘀阻证)病人心绞痛症状以及降低中医证候积分的作用。2.银杏酮酯分散片可以改善冠心病稳定型心绞痛(心血瘀阻证)患者的心电图表现。3.银杏酮酯分散片能够减少冠心病稳定型心绞痛(心血瘀阻证)患者硝酸甘油的使用量。4.银杏酮酯分散片在实验进程中无不良反应的发生。
[Abstract]:Objective: To evaluate the Ginkgo biloba dispersible tablets on coronary heart disease with stable angina (blood stasis syndrome) in the treatment to improve the symptoms of angina pectoris, TCM syndrome, efficacy and safety of ECG, nitroglycerin withdrawal rate etc.. Methods: experimental observation using randomized, double-blind, positive drug control method March 2016, to November 2016 in the First Affiliated Hospital of Heilongjiang University Of Chinese Medicine in three patients, diagnosis and voluntarily agreed to meet the standard set of 60 patients with heart diseases were observed. The patients were randomly divided into treatment group (oral Ginkgo biloba dispersible tablets, 1 tablets each time, 3 times daily oral Ginaton analog., 1 tablets each time, 3 times daily) 32 cases and control group (oral Ginaton, 1 tablets each time, 3 times daily oral Ginkgo biloba dispersible tablets analog agent, 1 tablets each time, 3 times daily) in 28 cases, use 8W + 2D, after the observation of Ginkgo biloba Dispersible Tablets Treatment Chest pain (blood stasis syndrome) in TCM syndrome, symptoms of angina, ECG and nitroglycerin stop reduction rate of the curative effect. Results: 1. angina symptoms, the total effective rate of control group was 67.86%, the total effective rate of treatment group was 93.75%, two groups of patients with efficiency by rank sum test P0.05 there is significant difference in.2., TCM syndrome score, the treatment group and the control of TCM syndrome score were significantly different group of patients before and after treatment (P0.05), TCM syndrome curative effect, the total effective rate of control group was 71.43%, the total efficiency of the treatment group was 93.75%, two groups of TCM Syndrome curative effect the rank and inspection of P0.05, there were significant differences in.3. withdrawal rate of nitroglycerin, control group the total effective rate was 71.43%, the effective rate of treatment group was 93.75%, two groups of patients by rank test P0.05, there were significant differences in.4. frequency of angina pectoris, treatment The paired t test P0.05 group and control group after treatment treatment, there were statistically significant differences in the duration of angina pectoris, treatment group and control group after treatment of angina pectoris were reduced in duration, paired t test before and after P0.05, the difference was statistically significant.5. in electrocardiogram improvement, the total effective rate of the control group the 35.71%, the effective rate of treatment group was 50%, two groups of patients with efficiency by rank test P0.05, the difference was not statistically significant.6. two groups of liver, renal function index compared with the paired t test, treatment group and control group before and after treatment showed no significant difference (P0.05). Conclusion: with improved stability coronary heart disease angina pectoris 1. Ginkgo biloba dispersible tablets (blood stasis syndrome) in patients with angina symptoms and reduce the effects of Ginkgo biloba extract.2. TCM dispersible tablets can improve coronary heart disease with stable angina (blood stasis syndrome) in patients with ECG .3. ginkgo ketone dispersible tablets can reduce the use of nitroglycerin in patients with stable angina pectoris (heart blood stasis syndrome)..4. ginkgo ketone dispersible tablets had no adverse reactions in the experimental process.

【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.4

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