贝那普利联合美托洛尔治疗老年原发性高血压伴心力衰竭的疗效分析

发布时间：2018-04-10 21:53

本文选题：老年 + 原发性高血压　；参考：《中国药房》2017年27期

【摘要】：目的:观察贝那普利联合美托洛尔治疗老年原发性高血压伴心力衰竭的疗效和安全性。方法:回顾性分析100例老年原发性高血压伴心力衰竭患者资料,按用药方案的不同分为对照组(50例)和观察组(50例)。在常规治疗的基础上,对照组患者给予盐酸贝那普利片10 mg,口服,每日1次;观察组患者在对照组治疗的基础上给予酒石酸美托洛尔片初始剂量6.25 mg,口服,每日2次,后视患者病情,增加至50~100 mg,口服,每日2次。治疗6个月后观察两组患者的临床疗效,治疗前后收缩压(SBP)、舒张压(DBP)、肱-踝脉搏波传导速度(ba PWV)、静息心率、左室射血分数(LVEF)、每搏输出量(SV)及不良反应发生情况。结果:观察组患者总有效率(88.0%)显著高于对照组(62.0%),差异有统计学意义(P0.05)。治疗前,两组患者SBP、DBP、ba PWV、静息心率、LVEF、SV比较,差异均无统计学意义(P0.05)。治疗后,两组患者SBP、DBP、ba PWV均显著低于同组治疗前,且观察组显著低于对照组;两组患者LVEF、SV均显著高于同组治疗前,且观察组显著高于对照组;观察组患者静息心率显著低于同组治疗前及对照组,差异均有统计学意义(P0.05);但对照组治疗前后静息心率比较,差异无统计学意义(P0.05)。两组患者治疗期间均未见明显不良反应发生。结论:在常规治疗的基础上,贝那普利联合美托洛尔治疗老年原发性高血压伴心力衰竭的疗效显著,可改善患者心功能及血压,且安全性较好。
[Abstract]:Objective: to observe the efficacy and safety of benazepril combined with metoprolol in the treatment of elderly essential hypertension with heart failure.Methods: the data of 100 elderly patients with essential hypertension and heart failure were analyzed retrospectively and divided into two groups: control group (n = 50) and observation group (n = 50).On the basis of routine treatment, the patients in the control group were given benazepril hydrochloride 10 mg orally once a day, while the patients in the observation group were given the initial dose of metoprolol tartrate at an initial dose of 6.25 mg, twice a day, on the basis of the treatment in the control group.After the patient's condition, increased to 50 to 100 mg, oral, 2 times a day.After 6 months of treatment, the clinical effects of the two groups were observed. Systolic blood pressure (SBP), diastolic blood pressure (DBP), brachial-ankle pulse wave velocity (PWVV), resting heart rate (HR), left ventricular ejection fraction (LVEF), volume of stroke output (SVV) and adverse reactions were observed before and after treatment.Results: the total effective rate of observation group was significantly higher than that of control group (P 0.05).Before treatment, there was no significant difference in SBP, DBPBA PWV, resting heart rate and LVEFV between the two groups (P 0.05).After treatment, the PWV of SBP DBPnBA in the two groups were significantly lower than those in the same group and the observation group was significantly lower than that in the control group, and the SV of the two groups was significantly higher than that of the same group and the observation group was significantly higher than that of the control group.The resting heart rate in the observation group was significantly lower than that in the same group and the control group, the difference was statistically significant (P 0.05), but there was no significant difference in the resting heart rate before and after treatment in the control group (P 0.05).No significant adverse reactions occurred during treatment in both groups.Conclusion: benazepril combined with metoprolol can improve cardiac function and blood pressure in elderly patients with essential hypertension and heart failure.
【作者单位】：邳州市人民医院药剂科;邳州市人民医院心内科;
【分类号】：R541.6;R544.11

【相似文献】