EAT、IMA和hs-cTnT与急性冠状动脉综合征病变程度的相关性

发布时间：2018-04-11 02:35

本文选题：急性冠状动脉综合征 + 心外膜脂肪组织　；参考：《中国动脉硬化杂志》2017年01期

【摘要】：目的探讨心外膜脂肪组织(EAT)厚度、血清缺血修饰白蛋白(IMA)和高敏肌钙蛋白T(hs-cTnT)与急性冠状动脉综合征(ACS)的相关性。方法选择2014年9月至2015年11月我院收治的120例ACS患者作为病例组,其中单支病变组、双支病变组和多支病变组各40例。选择同期在我院进行体检的心功能正常健康者120例作为正常对照组,采用超声心动图测定EAT厚度,采用白蛋白-钴离子结合试验法测定血清IMA水平,采用电化学发光免疫分析法测定血清hs-cTnT水平。结果 ACS患者EAT厚度、IMA和hs-cTnT水平及Gensini积分均显著高于正常对照组(P0.01)。ACS患者单支病变组、双支病变组和多支病变组EAT厚度、IMA和hs-cTnT水平及Gensini积分变化均呈递增趋势,且均高于正常对照组(P0.01)。ACS患者EAT厚度、IMA和hs-cTnT水平与Gensini积分呈显著正相关(P0.01)。单支病变组患者IMA水平与Gensini积分具有相关性(P0.05),EAT厚度和hs-cTnT水平与Gensini积分无显著相关性(P0.05);双支病变组和多支病变组患者EAT厚度、IMA和hs-cTnT水平与Gensini积分均呈显著正相关(P0.05或P0.01)。结论 EAT厚度、IMA和hs-cTnT水平与ACS病变严重程度具有相关性。
[Abstract]:Objective to investigate the correlation between the thickness of epicardial adipose tissue (EATT), serum ischemia modified albumin (IMA) and troponin (TnTnT) in patients with acute coronary syndrome (ACS).Methods from September 2014 to November 2015, 120 patients with ACS were selected as the case group, including single vessel lesion group, double vessel lesion group and multi-vessel lesion group.The EAT thickness was measured by echocardiography and serum IMA level was measured by albumin cobalt ion binding test in 120 healthy patients with normal cardiac function who underwent physical examination in our hospital at the same time.The level of serum hs-cTnT was measured by electrochemiluminescence immunoassay (ECLIA).Results the levels of IMA and hs-cTnT and Gensini score in ACS patients were significantly higher than those in normal control group (P 0.01). The changes of EAT thickness and hs-cTnT and Gensini score in double vessel lesion group and multivessel lesion group were increased.The levels of IMA and hs-cTnT in EAT thickness were significantly higher than those in normal controls (P 0.01) and Gensini scores were significantly correlated with Gensini scores (P 0.01).There was no significant correlation between IMA level and Gensini score in single vessel lesion group. There was no significant correlation between Gensini score and IMA thickness and hs-cTnT level, but there was a significant positive correlation between EAT thickness and hs-cTnT level and Gensini score in double vessel lesion group and multivessel lesion group (P 0.05 or P 0.01).Conclusion the levels of IMA and hs-cTnT in EAT thickness are correlated with the severity of ACS.
【作者单位】：衡水市哈励逊国际和平医院心内科;衡水市哈励逊国际和平医院超声科;
【基金】：衡水市科学技术研究与发展计划项目(14020A)
【分类号】：R541.4

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