老年心房颤动患者外周血血管性血友病因子、E-选择素、细胞间黏附分子-1和血管细胞间黏附分子-1的水平变化

发布时间：2018-04-12 06:20

本文选题：心房颤动 + 血管性血友病因子　；参考：《中国老年学杂志》2017年21期

【摘要】：目的探讨老年心房颤动患者外周血血管性血友病因子(v WF)、E-选择素、细胞间黏附分子(ICAM)-1和血管细胞间黏附分子(VCAM)-1的水平。方法选择老年心房颤动患者238例(研究组),其中阵发性心房颤动组119例与持续性心房颤动组119例。另选老年健康体检者100例为对照组。所有研究对象于清晨空腹采集外周静脉血,分离血浆,采用酶联免疫吸附法测定v WF、E-选择素、ICAM-1和VCAM-1水平。结果研究组血浆v WF、E-选择素、ICAM-1和VCAM-1水平明显高于对照组(P0.05);持续性心房颤动组血浆v WF、E-选择素、ICAM-1和VCAM-1含量明显高于阵发性心房颤动组(P0.05);心房颤动患者v WF、E-选择素、ICAM-1和VCAM-1联合诊断灵敏度和特异度均明显高于单项指标。结论老年心房颤动患者v WF、E-选择素、ICAM-1和VCAM-1血浆水平明显升高,联合诊断具有较高的灵敏度和特异度。
[Abstract]:Objective to investigate the levels of E- selectin, intercellular adhesion molecule (ICAM-1) and vascular intercellular adhesion molecule (VCAM-1) in peripheral blood of elderly patients with atrial fibrillation.Methods 238 elderly patients with atrial fibrillation (study group, 119 cases of paroxysmal atrial fibrillation group and 119 cases of persistent atrial fibrillation group) were selected.Another 100 cases were selected as control group.Plasma was isolated from peripheral venous blood collected on an empty stomach in the morning. The levels of ICAM-1 and VCAM-1 were measured by enzyme-linked immunosorbent assay (Elisa).Results the plasma levels of vWF- E- selectin ICAM-1 and VCAM-1 in the study group were significantly higher than those in the control group (P0. 05), the plasma vWF- E- selectin-selectin-ICAM-1 and VCAM-1 levels in the patients with persistent atrial fibrillation were significantly higher than those in the paroxysmal atrial fibrillation group (P0. 05).The sensitivity and specificity of combined diagnosis with VCAM-1 were significantly higher than that of single index.Conclusion the plasma levels of vWF- E- selectin ICAM-1 and VCAM-1 in elderly patients with atrial fibrillation were significantly increased, and the combined diagnosis had high sensitivity and specificity.
【作者单位】：温州医科大学附属台州医院心内科;温州医科大学附属台州医院医学研究中心;
【分类号】：R541.75

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