颈动脉冷盐水灌注对低温性心脏骤停复苏犬模型的神经保护作用

发布时间：2018-04-15 09:36

  本文选题：心脏停搏 + 心肺复苏　； 参考：《解放军医学杂志》2017年10期

【摘要】：目的评价颈动脉冷盐水灌注(ICSI)对严重低体温所致心脏骤停犬心肺复苏后脑组织功能的保护作用。方法对10只低体温致心脏骤停比格犬进行心肺复苏,待自主循环恢复(ROSC)后随机分为对照组和实验组,每组5只。对照组接受常规温水浴复温,实验组在温水浴复温基础上进行ICSI,使脑部温度低于36℃并维持6h。ROSC 24h后记录两组神经功能受损评分(NDS)、血清脑组织损伤生物标志物s100β蛋白水平、脑组织含水量和组织病理学变化。结果实验组血清s100β蛋白水平(119.83±42.93pg/ml vs.329.82±190.39pg/ml,P0.05)和脑组织含水量(79.43%±0.72%vs.80.79%±1.06%,P0.05)明显低于对照组。对照组脑海马组织锥体细胞损伤更重。两组间NDS评分差异无统计学意义。结论 ICSI可减少低体温所致心脏骤停犬s100β的产生,减轻脑组织病理损伤。
[Abstract]:Objective to evaluate the protective effect of cold saline infusion of carotid artery (ICSII) on brain function after cardiopulmonary resuscitation (CPR) in dogs with severe hypothermia.Methods Cardiopulmonary resuscitation (CPR) was performed in 10 hypothermia induced cardiac arrest Beagle dogs. After the recovery of autonomic circulation, 10 dogs were randomly divided into control group and experimental group with 5 in each group.The control group received routine warm water bath rewarming, the experimental group was treated with ICSI on the basis of warm water bath rewarming, the brain temperature was lower than 36 鈩，

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