新疆地区维吾尔族、哈萨克族与汉族原发性高血压并发左室肥厚与血清FGF2的相关性分析

发布时间：2018-04-15 19:09

本文选题：高血压 + 左室肥厚　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:通过测定新疆地区维吾尔族、哈萨克族与汉族原发性高血压(Essential Hpertension,EH)患者外周血清FGF2(Fibroblast Growth Factor2,FGF2)的表达水平,比较三民族间血清FGF2的水平差异,并探讨EH并发左室肥厚(Left Ventricular Hypertrophy,LVH)与血清FGF2的相关性。方法:选择2014年9月至2016年3月期间在新疆医科大学第一附属医院高血压科住院的原发性高血压患者进行研究,共302例,其中汉族120例,维吾尔族85例,哈萨克族97例。收集患者的一般临床资料及血生化、心脏B超等检查结果,通过酶联免疫吸附法(ELISA)测定外周血清FGF2水平。比较三民族EH患者血清FGF2水平差异;并根据入选患者的心脏B超结果,分为左室肥厚组(LVH组)与非左室肥厚组(NLVH组)。比较LVH组与NLVH组EH患者的血清FGF2对表达水平差异,并探讨性别、年龄、BMI、FBG、Scr、LVEF与EH并发LVH的相关性。结果:(1)比较三民族EH患者血清FGF2水平,维吾尔族EH患者血清FGF2水平明显高于汉族与哈萨克族(p0.05),汉族与哈萨克族之间无统计学差异(p0.05)。(2)汉族、维吾尔族、哈萨克族EH患者的LVMI逐渐增加,且相同民族EH患者中NLVH组的血清FGF2水平均较LVH组高,差异均有统计学差异(p均0.05)。(3)三民族EH患者中血清FGF2浓度与LVMI均呈正相关(p0.05)。结论:血清FGF2水平存在民族差异,且在高血压并非左室肥厚过程中可能起着一定作用。
[Abstract]:Objective: to determine the expression of FGF2(Fibroblast Growth Factor2FGF2 in the peripheral blood of Uygur, Kazak and Han patients with essential hypertension (EH) in Xinjiang, and to compare the serum FGF2 levels among the three nationalities.To investigate the relationship between left Ventricular hypertrophy (LVH) and serum FGF2 in patients with EH.Methods: from September 2014 to March 2016, 302 patients with essential hypertension in the Department of Hypertension, first affiliated Hospital of Xinjiang Medical University, including 120 Han, 85 Uygur and 97 Kazak, were selected.The general clinical data, blood biochemistry, heart B ultrasound and other results were collected. The FGF2 level in peripheral blood was measured by enzyme linked immunosorbent assay (Elisa).The serum FGF2 levels of EH patients were compared and divided into left ventricular hypertrophy group (LVH group) and non-left ventricular hypertrophy group (NLVH group) according to the results of echocardiography.To compare the expression of serum FGF2 in patients with EH in LVH group and NLVH group, and to explore the correlation between sex, age and BMIFBGG Scr-LVEF and EH complicated with LVH.Results the serum FGF2 level of EH patients in Uygur nationality was significantly higher than that in Han nationality and Kazak nationality, and there was no significant difference between Han nationality and Kazak nationality in the level of serum FGF2 (p 0.05. 2) the level of serum FGF2 in Uygur EH patients was significantly higher than that in Han nationality and Kazakh nationality.The level of serum FGF2 in NLVH group was higher than that in LVH group (P < 0.05).Conclusion: there are ethnic differences in serum FGF2 levels, and may play a role in the process of hypertension not left ventricular hypertrophy.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R544.11

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