老年房颤患者血浆apelin水平及与N端B型利钠肽前体和左房内径的关系

发布时间：2018-04-15 22:08

本文选题：房颤 + apelin　；参考：《中国老年学杂志》2017年12期

【摘要】：目的探讨老年房颤患者血浆apelin的表达水平及其与N端B型利钠肽前体(NT-pro BNP)、左房内径(LAD)的关系。方法 122例老年房颤患者,其中53例为阵发性房颤(阵发组),36例为持续性房颤(持续组),33例为永久性房颤(永久组),并于同期随机选取40例非房颤患者为对照组,采用酶联免疫吸附法(ELISA)检测血浆apelin和NT-pro BNP水平,心脏多普勒超声诊断仪测定LAD、左心室射血分数(LVEF),并分析apelin与NT-pro BNP、LAD的关系。结果阵发组、持续组、永久组血浆apelin水平低于对照组,持续组、永久组血浆apelin水平低于阵发组,永久组血浆apelin水平低于持续组(P0.05);阵发组、持续组、永久组NT-pro BNP、LAD高于对照组,持续组、永久组NT-pro BNP、LAD高于阵发组,永久组NTpro BNP、LAD高于持续组(P0.05)。经Pearson积矩相关分析,老年房颤患者血浆apelin与NT-pro BNP、LAD均呈负相关关系(r=-0.675、-0.772,P0.05)。结论老年房颤患者血浆apelin水平降低,并且apelin通过抗纤维化作用而参与心肌重构,进而参与房颤的发生及维持过程。
[Abstract]:Objective to investigate the expression of plasma apelin in elderly patients with atrial fibrillation and its relationship with N-terminal B-type natriuretic peptide precursor NT-pro BNPN, left atrial diameter (lad).Methods among 122 elderly patients with atrial fibrillation, 53 cases were paroxysmal atrial fibrillation (36 cases in the paroxysmal group were persistent atrial fibrillation, 33 cases in the persistent group were permanent atrial fibrillation (permanent group), and 40 cases were randomly selected as the control group in the same period.Plasma apelin and NT-pro BNP levels were detected by Elisa, lad, left ventricular ejection fraction (LVEF) were measured by echocardiography, and the relationship between apelin and NT-pro BNPLAD was analyzed.Results the plasma apelin level of paroxysmal group, persistent group and permanent group was lower than that of control group, the plasma apelin level of permanent group was lower than that of paroxysmal group, the plasma apelin level of permanent group was lower than that of continuous group (P0.05), and that of paroxysmal group, persistent group and permanent group was higher than that of control group.In the persistent group, the NT-pro BNP-LAD in the permanent group was higher than that in the paroxysmal group, and the NTpro BNPLAD in the permanent group was higher than that in the persistent group (P0.05).By Pearson moment correlation analysis, there was a negative correlation between plasma apelin and NT-pro BNPLAD in elderly patients with atrial fibrillation.Conclusion the level of plasma apelin in elderly patients with atrial fibrillation is decreased, and apelin participates in myocardial remodeling through anti-fibrosis, and then participates in the occurrence and maintenance of atrial fibrillation.
【作者单位】：河北大学附属医院麻醉科;河北大学附属医院心内科;
【基金】：河北省科技计划项目(No.132777159)
【分类号】：R541.75

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