含硫气体信号分子对心血管调节的效应及机制研究进展

发布时间：2018-04-18 01:16

本文选题：硫化氢 + 二氧化硫　；参考：《生理科学进展》2017年01期

【摘要】：含硫气体信号分子硫化氢(hydrogen sulfide,H2S)和二氧化硫(sulfur dioxide,SO2)过去被认为是废气,但是研究先后发现这两种含硫气体能在哺乳动物体内通过含硫氨基酸代谢内源性生成。心血管系统存在H2S和SO2的生成体系,并且H2S和SO2具有重要的心血管生理学效应,包括舒张血管和心肌负性肌力作用。H2S和SO2的心血管病理生理学效应也逐渐被认识,如缓解高血压和肺动脉高压、抑制动脉粥样硬化进展、保护心肌缺血再灌注损伤和异丙肾诱导的心肌损伤。ATP敏感性钾通道、L型钙通道、c GMP、NF-κB信号通路及MAPK信号通路等都参与H2S和SO2的生物学效应。以上发现表明H2S和SO2是重要的心血管内源性气体信号分子,为阐明心血管疾病的发病机制和治疗靶点提供新的思路。
[Abstract]:Sulfur gas signaling molecule hydrogen sulfide H _ 2S) and sulfur dioxide sulfur dioxide so _ 2) were considered as exhaust gases in the past. However, it has been found that these two kinds of sulfur-containing gases can be produced endogenously in mammalian body through the metabolism of sulfur-containing amino acids.There are H2S and SO2 production systems in the cardiovascular system, and H2S and SO2 have important cardiovascular physiological effects, including vasodilator and myocardial negative inotropic effects. H2S and SO2 have been gradually recognized as cardiovascular pathophysiological effects.Such as relieving hypertension and pulmonary hypertension, inhibiting the progression of atherosclerosis,Protecting myocardial ischemia-reperfusion injury and isopropylene-induced myocardial injury. ATP-sensitive potassium channel, L-type calcium channel, c-GMP- 魏 B signaling pathway and MAPK signaling pathway are involved in the biological effects of H2S and SO2.These findings suggest that H _ 2S and SO2 are important endogenous gas signaling molecules in the cardiovascular system and provide new ideas for elucidating the pathogenesis and therapeutic targets of cardiovascular diseases.
【作者单位】：北京大学第一医院儿科;北京大学医学部生理学与病理生理学系;
【分类号】：R54

【相似文献】