中药动员方在自体造血干细胞移植中辅助动员外周血干细胞的疗效观察

发布时间：2018-04-18 04:04

本文选题：中药动员方 + 造血干细胞移植　；参考：《中医杂志》2017年24期

【摘要】：目的观察中药动员方辅助化疗+重组人粒细胞集落刺激因子(rh G-CSF)在自体造血干细胞移植(auto-HSCT)中动员外周血干细胞的疗效。方法 10例接受auto-HSCT治疗的血液肿瘤患者在化疗+rh GCSF动员外周血干细胞的基础上,同时服用中药动员方,每日1剂,全程服用中药动员方直至采集结束。对患者动员及采集结果进行观察,记录造血重建时间,并观察不良反应。结果 10例患者中有7例采集一次成功,3例采集两次成功;所有患者第一次采集单个核细胞数平均为(6.92±3.32)×108/kg,第一次采集CD34+细胞数平均为(3.66±2.50)×106/kg;所有患者行auto-HSCT后粒系植入中位时间为10天,血小板植入中位时间为12.50天;动员与采集过程中均无严重不良反应及感染发生。结论中药动员方辅助化疗+rh G-CSF在auto-HSCT中可增强动员外周血干细胞的效果,提高一次采集成功率,短时间内实现造血重建,且安全性较好。
[Abstract]:Objective to observe the effect of mobilization of peripheral blood stem cells (PBSCs) in autologous hematopoietic stem cell transplantation (auto-HSCT) by recombinant human granulocyte colony stimulating factor (rh G-CSF).Methods on the basis of rh GCSF mobilization of peripheral blood stem cells, 10 patients with hematologic tumor treated with auto-HSCT were treated with traditional Chinese Medicine Mobilization Formula once a day, and the whole course was treated with TCM Mobilization recipe until the end of collection.Patient mobilization and collection results were observed, hematopoietic reconstitution time was recorded, and adverse reactions were observed.Results among 10 patients, 7 cases were successfully collected once and 3 cases were successfully collected twice. The average number of mononuclear cells collected for the first time was 6.92 卤3.32 脳 10 ~ 8 / kg, and the average number of CD34 cells collected for the first time was 3.66 卤2.50 脳 10 ~ (-6) 路kg ~ (-1) 脳 10 ~ (-6) 路kg ~ (-1), the median time for auto-HSCT posterior granulocyte implantation was 10 days.The median time of platelet implantation was 12.50 days, and there was no serious adverse reaction and infection during mobilization and collection.Conclusion Rh G-CSF can enhance the mobilization of peripheral blood stem cells in auto-HSCT, improve the success rate of single acquisition, and achieve hematopoietic reconstitution in a short time, and the safety is good.
【作者单位】：山东中医药大学第一临床医学院;山东中医药大学附属医院;
【基金】：国家自然科学基金(81473511)
【分类号】：R457.7;R733

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