二维斑点追踪技术评价兔急、慢性心肌梗死心肌圆周应变

发布时间：2018-04-19 19:42

本文选题：心肌梗塞 + 超声心动描记术　；参考：《中国临床医学影像杂志》2017年06期

【摘要】：目的:探讨二维斑点追踪技术评价兔急、慢性心肌梗死心肌整体圆周应变及应变率的变化。方法 :将25只新西兰兔分成假手术组(n=5),仅开胸;实验组(n=20),开胸,结扎左回旋支90 min后松开活结,分别于术前、术后1周、7周测量左室短轴观3个水平(二尖瓣、乳头肌及心尖水平)的心肌整体圆周应变(GCS)和应变率(GSrC),以绝对值进行分析。实验结束后,行在体心脏磁共振(c MRI)检查和离体心肌氯化三苯基四氮唑(TTC)染色,分别测量心肌梗死面积(MI size%)等。结果:二尖瓣水平:与术前比较,术后1周组GCS及GSr C均显著增高(P0.05);与术后1周组比较,术后7周组GCS及GSrC均显著降低(P0.05),基本回落到术前基础状态(P0.05)。乳头肌和心尖水平:与术前比较,术后两组GCS及GSrC均显著降低(P0.05),而术后两组比较,GCS及GSr C差异均无统计学意义(P0.05)。假手术组:3个水平各时间段GCS、GSrC比较,均无统计学意义(P0.05)。相关性分析显示:乳头肌水平GCS、GSr C分别与LVEF(US)、LVEF(cMRI)、MI size%相关性较好(r分别为-0.943、-0.916、-0.749、-0.615、0.807、0.641,P0.05)。结论 :二维斑点追踪技术可以评价兔急、慢性心肌梗死心脏局部及整体功能,并判断心肌梗死部位及范围。
[Abstract]:Objective: to evaluate the changes of global peripheral strain and strain rate in acute and chronic myocardial infarction by two-dimensional speckle tracing technique. Methods: Twenty-five New Zealand rabbits were divided into sham operation group (n = 5) and experimental group (n = 20), the left circumflex branch was ligated for 90 min, and the left ventricular short axis was measured at 3 levels (mitral valve) before operation and 1 week after operation. The global circumferential strain (GCSs) and strain rate (GSrCX) of the papillary muscle and apical muscle were analyzed with absolute value. At the end of the experiment, cardiac magnetic resonance imaging (MRI) in vivo and TTCstaining of triphenyltetrazolium chloride (TTC) in isolated myocardium were performed to measure myocardial infarction area (MI size). Results: the level of mitral valve: GCS and GSr C increased significantly at 1 week after operation compared with those before operation, and GCS and GSrC decreased significantly in 7 weeks after operation compared with that in postoperative 1 week group, and basically decreased to the basic state of P0.05 before operation. The levels of papillary muscle and apical muscle: compared with those before operation, GCS and GSrC in the two groups decreased significantly (P 0.05), but there was no significant difference in GSr C and GCS between the two groups after operation (P 0.05). In sham-operation group, there was no significant difference in GSrC between three levels of GCSP and GSrC (P 0.05). The correlation analysis showed that the correlation between GCSC and LVEFU cMRI size% was -0.943 ~ 0.916 ~ (-0.749) ~ (-0.615) ~ (0.807) ~ (0.641) ~ (0.64) ~ (-1) (P = 0.05) respectively. Conclusion: the two-dimensional speckle tracing technique can be used to evaluate the regional and global function of acute and chronic myocardial infarction in rabbits and to judge the location and extent of myocardial infarction.
【作者单位】：大连医科大学附属第二医院超声科;比利时天主教鲁汶大学Gasthuisbeg医院放射科;
【分类号】：R540.45;R542.22

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