炎症反应与慢性阻塞性肺疾病相关肺动脉高压及其血液高凝状态的关系

发布时间：2018-04-22 02:04

本文选题：慢性阻塞性肺疾病 + 肺动脉高压　；参考：《山东医药》2017年01期

【摘要】：目的探讨炎症反应与慢性阻塞性肺疾病(COPD)相关肺动脉高压及其高凝状态的关系。方法收集COPD患者80例,根据心脏超声估测肺动脉收缩压(PASP),以PASP 40 mm Hg为界将患者分为COPD伴肺动脉高压组和COPD无肺动脉高压组两组(每组40例),检测两组血清C反应蛋白(CRP)、白介素6(IL-6)、白介素8(IL-8)、肿瘤坏死因子-α(TNF-α)、脑钠肽(BNP)、D-二聚体(D-D)、纤维蛋白原(FIB)、红细胞压积(HCT),比较两组各项检测的差异,分析炎性因子与肺动脉压、D-D的相关性以及肺动脉高压、高凝状态的影响因素。结果肺动脉高压组血清CRP、IL-6、IL-8、TNF-α、D-D、FIB、BNP水平高于无肺动脉高压组(P均0.05)。偏相关性分析显示,CRP、IL-6、IL-8水平与PASP呈正相关,Pa O2与PASP呈负相关(r分别为0.387、0.611、0.412、-0.576,P均0.05),CRP水平与D-D呈正相关(r=0.379,P0.05)。二元Logistic回归分析示,CRP、IL-8、TNF-α为肺动脉高压的危险因素;Pa O2为其保护因素;CRP、IL-6为血液高凝状态的危险因素。结论炎症反应及其炎症因子对COPD相关肺动脉高压及其血液高凝状态形成有重要作用。
[Abstract]:Objective to investigate the relationship between inflammatory response and pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD) and its hypercoagulability. Methods 80 patients with COPD were collected. The patients were divided into two groups: COPD with pulmonary hypertension and COPD without pulmonary hypertension (40 cases in each group). The serum C-reactive protein (CRP), interleukin-6 (IL-6) IL-6 and white medium were detected in the two groups according to echocardiographic estimation of pulmonary arterial systolic blood pressure (PAP). TNF- 伪, TNF- 伪, BNP, FIBB, HCT and HCT were compared between the two groups. To analyze the correlation between inflammatory factors and pulmonary artery pressure D-D, and the influencing factors of pulmonary hypertension and hypercoagulability. Results the serum levels of TNF- 伪 D and FIBN BNP in patients with pulmonary hypertension were higher than those in patients without pulmonary hypertension (P < 0.05). The partial correlation analysis showed that the level of IL-6 IL-8 was positively correlated with PASP, and there was a negative correlation between PASP and Pao _ 2, r was 0.387V 0.6110.412 ~ -0.576p, respectively, and there was a positive correlation between IL-8 level and D-D, 0.379m P0.05a. Binary Logistic regression analysis showed that IL-8 TNF- 伪 was the risk factor of pulmonary hypertension and PAO _ 2 was its protective factor and IL-6 was the risk factor of hypercoagulability. Conclusion inflammatory reaction and its inflammatory factors play an important role in the formation of COPD associated pulmonary hypertension and hypercoagulability.
【作者单位】：武汉市中心医院;武汉大学人民医院;
【分类号】：R563.9;R544.1

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