不同激动剂引起大鼠肺动脉主干与三级分支收缩反应的比较

发布时间：2018-04-24 11:15

本文选题：肺动脉主干 + 肺动脉三级分支　；参考：《生理学报》2017年01期

【摘要】：为观察苯肾上腺素(phenylephrine,Phen)、内皮素-1(endothelin-1,ET-1)和KCl引起大鼠肺动脉主干与三级分支间收缩反应的差异,本文分别用传统的大血管张力检测技术和DMT微血管张力检测技术,记录KCl、Phen和ET-1引起的去内皮肺动脉主干和三级分支血管张力变化。结果显示:Phen可引起肺动脉主干显著收缩,但是不引起肺动脉三级分支的明显收缩;与肺动脉主干相比,ET-1导致肺动脉三级分支的收缩反应减弱,反应的最大值和亲和力指数(pD_2)值均降低;与肺动脉主干相比,KCl引起肺动脉三级分支的收缩反应增强。上述结果说明,肺动脉主干和肺动脉三级分支的血管反应性存在差异,进行肺小动脉血管功能研究具有重要意义。本实验可为进一步研究肺动脉小分支的血管功能及其在肺高压中的改变提供重要实验依据。
[Abstract]:In order to observe the difference between phenylephrine pheno, endothelin-1 endothelin-1 ET-1 (et 1) and KCl induced contractile response between the main and tertiary branches of pulmonary artery in rats, the traditional technique of macrovascular tension and the technique of microvascular tension of DMT were used in this study. The changes of arterial tension induced by KCl-Phen and ET-1 in the main and tertiary branches of the deendothelified pulmonary artery were recorded. The results showed that: 1 Phen induced significant contraction of pulmonary artery trunk, but did not cause significant contraction of third grade pulmonary artery branch, compared with pulmonary artery trunk, ET-1 induced a weaker contractile response of third grade pulmonary artery branch. The maximum response and affinity index (pD2) decreased, and KCl increased the contractile response of the tertiary branches of the pulmonary artery compared with the pulmonary trunk. These results suggest that there are differences in vascular reactivity between the main pulmonary artery and the tertiary branches of the pulmonary artery, and it is of great significance to study the vascular function of the pulmonary arterioles. This study may provide an important experimental basis for the further study of the vascular function of pulmonary artery branches and its changes in pulmonary hypertension.
【作者单位】：福建医科大学基础医学院生理学与病理生理学系;福建医科大学心血管科学研究室;泉州医学高等专科学校;
【基金】：supported by the National Natural Science Foundation of China(No.31371165 and 31571179) the Natural Science Foundation of Fujian Province,China(No.2015J01313) the Youth Research Project of Fujian Provincial Department of Health,China(No.2013-1-21)
【分类号】：R544.1

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