聚氧化乙烯改善大鼠慢性缺血后肢的血液灌注

发布时间：2018-04-24 13:31

本文选题：聚氧化乙烯 + 动脉形成　；参考：《南方医科大学学报》2017年01期

【摘要】：目的通过声学造影评价聚氧化乙烯(PEO)改善大鼠慢性缺血后肢的血液灌注的效果。方法 12只Wistar大鼠通过结扎一侧股动脉建立慢性后肢缺血模型,然后将大鼠随机分为实验组及对照组(n=6),隔天分别经颈内静脉输注PEO和生理盐水,共治疗2周。在不同的时间点行声学造影检查测定大鼠缺血后肢骨骼肌的血流量并在第28天测量血流储备量。结果从第7天开始PEO组大鼠缺血后肢骨骼肌的血流量高于对照组(P0.05),第28天时PEO组缺血后肢骨骼肌血流储备量及血管容积均显著高于对照组(P0.05)。结论 PEO显著提高了慢性后肢缺血模型大鼠骨骼肌的血流储备量和血流量,增加慢性缺血后肢骨骼肌的血管容积,提示PEO可能通过增加血流剪切力促进血管新生及动脉形成过程,从而改善缺血后肢的血液灌注。
[Abstract]:Objective to evaluate the effect of polyvinyl oxide (PEO) on blood perfusion of hind limbs after chronic ischemia in rats. Methods the chronic hindlimb ischemia model was established in 12 Wistar rats by ligation of unilateral femoral artery. Then the rats were randomly divided into two groups: experimental group and control group. PEO and normal saline were infused through internal jugular vein the next day for 2 weeks. The blood flow of skeletal muscle of hind limb was measured at different time points by contrast echocardiography and blood flow reserve was measured on the 28th day. Results from the 7th day, the blood flow of hind limb skeletal muscle in PEO group was higher than that in control group (P 0.05), and the blood flow reserve and blood vessel volume of hind limb skeletal muscle in PEO group were significantly higher than that in control group on the 28th day. Conclusion PEO can significantly increase the blood flow reserve and blood flow of skeletal muscle in rats with chronic hind limb ischemia, and increase the volume of blood vessels in the skeletal muscle of chronic hind limb ischemia. The results suggest that PEO may improve the blood perfusion of hind limbs after ischemia by increasing the shear stress of blood flow and promoting angiogenesis and arteriogenesis.
【作者单位】：南方医科大学第三附属医院;南方医科大学南方医院;
【基金】：广东省自然科学基金(2012010009316) 南方医科大学南方医院院长基金(2013Z002)
【分类号】：R543

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