住院精神分裂症患者心血管疾病发生风险研究

发布时间：2018-04-25 23:10

  本文选题：精神分裂症 + 心血管疾病　； 参考：《中国神经精神疾病杂志》2017年09期

【摘要】：目的探讨住院精神分裂症患者心血管疾病风险特征和预测精神分裂症患者未来10年发生心血管疾病风险。方法随机收集住院精神分裂症患者466例,测定患者组体质指数(body mass index,BMI)、空腹血糖(fasting plasma glucose,FBG)、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、吸烟率(吸烟人数/总人数)、高密度脂蛋白(high density lipoprotein-cholesterol,HDL-C)、Framing-ham心血管疾病发生风险评分(Framing-ham risk score,FRS)和血管年龄等指标,并与507例健康对照进行比较。其中10年心血管疾病发生风险和血管年龄用Framing-ham心血管疾病风险评分表来计算。结果住院精神分裂症患者未来10年发生心血管疾病的风险高于对照组[(6.71%±6.95%)vs.(4.76%±3.07%)],差异有统计学意义(P0.05);与对照组相比,患者组的吸烟率[(41%)vs.(19%)]、代谢综合征患病率[(25%)vs.(17%)]、BMI水平[(23.67±3.61)kg/m~2 vs.(21.73±4.11)kg/m~2]和血管年龄[(46.7±15.3)岁vs.(43.7±9.8)岁]增加(P0.05);SBP[(119.86±14.90)mmHg vs.(128.10±15.41)mmHg]和HDL-C水平[(1.08±0.27)mmol/L vs.(1.38±0.22)mmol/L]降低(P0.05)。患者组的FRS总分与BMI、FBG、SBP、腰围及吸烟指数均呈正相关(P0.05),与HDL-C呈负相关(P0.05)。多因素线性回归分析示,FRS总分与FBG(β=0.181,P0.01)、SBP(β=0.149,P0.01)、HDL-C(β=-0.107,P0.01)和吸烟指数(吸烟支数×吸烟年数)(β=0.554,P0.01)有关联。结论研究发现住院精神分裂症患者未来10年发生心血管疾病的风险为6.7%,显著高于对照组。空腹血糖、收缩压、高密度脂蛋白、吸烟可能与精神分裂症患者未来10年发生心血管疾病有关联。
[Abstract]:Objective to investigate the risk characteristics of cardiovascular disease in inpatients with schizophrenia and to predict the risk of cardiovascular disease in schizophrenic patients in the next 10 years. Methods A total of 466 inpatients with schizophrenia were randomly collected. Body mass index (BMI), fasting plasma glucose (FBG), triglyceride (TG), total cholesterol (TC), smoking rate (number of smokers / total number of people), high density lipoprotein-cholesterol (HDL-C) and Framing-ham cardiovascular disease risk scores (Framing-ham risk scoreFRSs) were measured. The results were compared with 507 healthy controls. Ten-year cardiovascular disease risk and vascular age were calculated using the Framing-ham cardiovascular disease risk scale. Results the risk of cardiovascular disease in inpatients with schizophrenia in the next 10 years was higher than that in the control group (6.71% 卤6.95% 卤4.76% 卤3.07%), and the difference was statistically significant (P 0.05). 鎮ｈ，

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