心房颤动患者血清Apelin水平与炎症关系的研究
发布时间：2018-04-27 01:37
本文选题：心房颤动 + Apelin ； 参考：《中国胸心血管外科临床杂志》2015年10期
【摘要】：目的研究心房颤动(房颤)患者血清Apelin水平与炎症的关系。方法选取2014年10~12月在我院心血管外科住院拟行心脏瓣膜手术的心脏瓣膜病患者58例,根据心电图或动态心电图及病史确定患者有无持续性房颤,将患者分为房颤组和窦性心律组。房颤组29例,男14例、女15例,年龄(57±8)岁;窦性心律组29例,男20例、女9例,年龄(54±10)岁。应用心脏彩色超声检测左心房内径和射血分数,酶联免疫吸附法测定血清中apelin、白细胞介素-6(IL-6)水平,免疫透射比浊法检测超敏C反应蛋白(hs-CRP)水平。结果与窦性心律组比较,房颤组血清Apelin[(201.94±71.96)pg/ml vs.(286.72±129.33)pg/ml]和射血分数(54.52%±3.94%vs.56.41%±2.85%)显著降低,hs-CRP[(5.58±12.90)mg/L vs.(1.89±3.55)mg/L]、IL-6[(2.59±0.64)pg/ml vs.(2.26±0.55)pg/ml]和左心房内径[(57.10±11.69)mm vs.(43.07±5.31 mm)]显著升高,差异均有统计学意义(P0.05)。相关分析显示:血清Apelin水平与超敏C反应蛋白、左心房内径呈负相关(r=-0.308,P=0.019;r=-0.313,P=0.017),Apelin与射血分数呈正相关(r=0.265,P=0.044)。结论房颤患者血清Apelin水平显著降低,炎症因子水平显著上升,Apelin可能与房颤、炎症密切相关,Apelin可能通过调节炎症反应从而参与房颤的发生与维持。
[Abstract]:Objective to study the relationship between serum Apelin level and inflammation in patients with atrial fibrillation (AF). Methods from October to December 2014, 58 patients with valvular heart disease who were hospitalized in our hospital from October to December 2014 were selected. According to electrocardiogram (ECG), dynamic electrocardiogram (ECG) and history of disease, the patients had persistent atrial fibrillation (AF). Patients were divided into atrial fibrillation group and sinus rhythm group. There were 29 patients with atrial fibrillation, 14 males and 15 females, aged 57 卤8 years, and 29 patients with sinus rhythm, 20 males and 9 females, aged 54 卤10 years. Left atrial diameter and ejection fraction were measured by color echocardiography, serum apelin and interleukin-6 (IL-6) levels were measured by enzyme-linked immunosorbent assay (Elisa), and hypersensitive C-reactive protein hs-CRP (hs-CRP) levels were detected by immuno-transmission turbidimetry. 缁撴灉涓庣鎬у績寰嬬粍姣旇緝,鎴块ⅳ缁勮娓匒pelin[(201.94卤71.96)pg/ml vs.(286.72卤129.33)pg/ml]鍜屽皠琛，
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