肺炎衣原体感染及炎症反应与冠心病的关系

发布时间：2018-04-28 12:59

本文选题：白细胞介素- + C-反应蛋白　；参考：《中华医院感染学杂志》2017年23期

【摘要】：目的探讨肺炎衣原体感染、炎症反应与冠心病的关系。方法选择2014年1月-2016年12月于医院诊断及治疗的冠心病患者80例为研究对象,分为急性心肌梗死组40例,心绞痛组40例,另选择同期健康体检者40名为对照组;检测并分析各组白细胞介素-6(IL-6)、C-反应蛋白(CRP)、纤维蛋白原(Fg)以及肺炎衣原体特异性抗体IgM以及IgG水平的差异,分析IL-6、CRP、Fg与心绞痛危险评分的关系,分析肺炎衣原体特异性抗体与IL-6、CRP、Fg的关系。结果急性心肌梗死组IL-6、CRP及Fg水平高于心绞痛组及对照组,心绞痛组高于对照组(P0.05);心绞痛患者随着危险分数的升高,IL-6、CRP及Fg水平也呈上升的趋势(P0.05);急性心肌梗死组与心绞痛组肺炎衣原体特异抗体IgG阳性率高于对照组(P0.05);IgG阳性患者IL-6及CRP水平高于阴性患者(P0.05);Pearson相关分析结果显示,肺炎衣原体特异性抗体IgG阳性与IL-6、CRP及Fg呈正相关关系(r=0.441,0.472,0.395,P0.05)。结论冠心病患者肺炎衣原体特异性抗体IgG水平升高,并且IgG与炎性指标有正相关关系,因此推断肺炎衣原体感染在冠心病的发生及发展过程中也发挥了重要的作用。
[Abstract]:Objective to investigate the relationship between Chlamydia pneumoniae infection, inflammatory response and coronary heart disease. Methods 80 patients with coronary heart disease diagnosed and treated in December -2016 in January 2014 were selected as subjects, including 40 cases of acute myocardial infarction, 40 cases of angina pectoris group, and 40 control groups in the same period of health examination. The relationship between -6 (IL-6), C- reactive protein (CRP), fibrinogen (Fg) and Chlamydia pneumoniae specific antibody IgM and IgG levels, analysis of the relationship between IL-6, CRP, Fg and the risk score of angina pectoris, and analysis of the relationship between Chlamydia pneumoniae specific antibodies and IL-6, CRP, and angina pectoris Group, angina group was higher than that of control group (P0.05); with the increase of risk score, the level of IL-6, CRP and Fg increased (P0.05), and the positive rate of Chlamydia pneumoniae specific antibody IgG positive rate in acute myocardial infarction group and angina group was higher than that of control group (P0.05); IL-6 and CRP levels in IgG positive patients were higher than that of negative patients (P0.05); Pearson related (P0.05); The results showed that the positive IgG of Chlamydia pneumoniae antibody was positively correlated with IL-6, CRP and Fg (r=0.441,0.472,0.395, P0.05). Conclusion the IgG level of Chlamydia pneumoniae specific antibody IgG in patients with coronary heart disease is elevated, and IgG is positively correlated with inflammatory indices. Therefore, the development and development of Chlamydia pneumoniae infection in coronary heart disease It also played an important role.

【作者单位】：舟山市妇幼保健院心内科;
【分类号】：R541.4

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