腺苷酸活化蛋白激酶对血管平滑肌细胞能量代谢重构调控机制研究进展

发布时间：2018-04-29 01:40

本文选题：腺苷酸活化蛋白激酶 + 血管平滑肌细胞　；参考：《中国临床药理学杂志》2017年18期

【摘要】：血管平滑肌细胞(VSMC)的异常增殖,是某些心血管疾病(如动脉粥样硬化、血管再狭窄、高血压和肺动脉高压等)共同的病理生理基础。在VSMC增殖过程中,伴随着细胞的能量代谢重构。调控VSMC能量代谢的因素有许多,如腺苷酸活化蛋白激酶(AMPK)、一氧化氮、活性氧及炎症因子等。其中,AMPK在调控能量代谢重构中起枢纽作用,多种因素可影响AMPK的表达或活性,包括遗传因素和非遗传因素。本文主要综述AMPK调控VSMC能量代谢重构作用及表观遗传因素和某些临床药物对AMPK调控的影响。
[Abstract]:The abnormal proliferation of vascular smooth muscle cells (VSMCs) is the common pathophysiological basis of some cardiovascular diseases such as atherosclerosis, restenosis, hypertension and pulmonary hypertension. During the process of VSMC proliferation, the energy metabolism of cells is reconstructed. Many factors regulate VSMC energy metabolism, such as adenylate activated protein kinase (AMPK), nitric oxide (no), reactive oxygen species (Ros) and inflammatory factors. AMPK plays a pivotal role in the regulation of energy metabolism remodeling, and many factors may affect the expression or activity of AMPK, including genetic and non-genetic factors. This article reviews the effects of AMPK on energy metabolism remodeling of VSMC, epigenetic factors and the effects of some clinical drugs on the regulation of AMPK.
【作者单位】：南华大学药物药理研究所血管生物学实验室湖南省分子靶标新药研究协同创新中心;
【基金】：国家自然科学基金资助项目(81173060) 分子靶标新药研究协同创新项目(湘教通(2014)405号) 南华大学归国人员基金资助项目(2010XQD44)
【分类号】：R54

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