红花黄色素治疗老年糖尿病肾病合并急性心肌梗死患者的临床观察

发布时间：2018-05-02 06:27

本文选题：红花黄色素 + 老年患者　；参考：《中国药房》2017年29期

【摘要】：目的:观察红花黄色素治疗老年糖尿病肾病合并急性心肌梗死的临床疗效及安全性。方法:选取我院2013年1月-2015年6月收治的老年糖尿病肾病合并急性心肌梗死患者102例作为研究对象,按照随机数字表法分为观察组(52例)和对照组(50例)。对照组患者给予抗凝,调脂,控制血糖、血压等常规治疗;观察组患者在对照组基础上加用注射用红花黄色素150 mg加入0.9%氯化钠注射液250 mL中,ivgtt,qd。两组患者均治疗2周。观察两组患者临床疗效,比较两组患者治疗前后肾功能指标[24小时微量蛋白定量(UMA)、血肌酐(Scr)、尿素氮(BUN)、血清总胆固醇(TC)、血清三酰甘油(TG)]、心功能指标[心脏射血分数(EF)、每搏输出量(SV)、心排出量(CO)、心脏指数(CI)]、炎症因子[C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)]和血液流变学指标(全血高切黏度、全血低切黏度、血细胞比容、纤维蛋白原、血小板凝聚率)。记录两组患者不良反应发生情况。结果:观察组患者的总有效率为96.15%,显著高于对照组的88.00%,差异有统计学意义(P0.05)。治疗前,两组患者肾功能指标、心功能指标、炎症因子、血液流变学指标比较,差异均无统计学意义(P0.05);治疗后,两组患者肾功能指标、炎症因子、血液流变学指标显著降低,心功能指标显著升高,且治疗组患者上述指标均显著优于对照组,差异均有统计学意义(P0.05)。两组患者均未见明显不良反应发生。结论:红花黄色素治疗老年糖尿病肾病合并急性心肌梗死患者疗效显著,能明显改善患者心肾功能,降低炎症因子水平,改善血液流变学指标,且安全性较高。
[Abstract]:Objective: to observe the efficacy and safety of safflower yellow in the treatment of senile diabetic nephropathy with acute myocardial infarction. Methods: 102 cases of senile diabetic nephropathy complicated with acute myocardial infarction were selected from January 2013 to June 2015, and were divided into two groups: observation group (n = 52) and control group (n = 50). The patients in the control group were treated with routine therapy such as anticoagulant, lipid regulation, blood glucose control and blood pressure control, and the patients in the observation group were treated with 150 mg safflower yellow pigment for injection plus 0.9% sodium chloride injection 250 mL for iv GTT QD on the basis of the control group. Both groups were treated for 2 weeks. To observe the clinical effect of the two groups, The indexes of renal function before and after treatment were compared between the two groups [24 hours of microprotein quantification (UMAA), creatinine (SCR), bun (bun), serum total cholesterol (TC), serum triacylglycerol (TG)], cardiac function index [cardiac ejection fraction (EF), ejection volume per stroke (SVG), cardiac output, cardiac output). Inflammatory cytokines [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor 伪 (TNF- 伪)] and hemorheology (whole blood high shear viscosity), Whole blood low shear viscosity, hematocrit, fibrinogen, platelet aggregation rate. Adverse reactions were recorded in both groups. Results: the total effective rate of the patients in the observation group was 96.15, which was significantly higher than that in the control group (88.00), and the difference was statistically significant (P 0.05). Before treatment, there was no significant difference in renal function index, cardiac function index, inflammatory factor, hemorheology index between the two groups, but after treatment, the renal function index, inflammatory factor and hemorheology index of the two groups were significantly decreased. The cardiac function index in the treatment group was significantly higher than that in the control group, and the difference was statistically significant (P 0.05). No significant adverse reactions occurred in both groups. Conclusion: the effect of safflower yellow on senile diabetic nephropathy patients with acute myocardial infarction is significant. It can obviously improve the heart and kidney function, reduce the level of inflammatory factors, improve the hemorheology index, and the safety is higher.
【作者单位】：淮安市第二人民医院心内科;
【分类号】：R542.22;R587.2;R692.9

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