非编码核糖核酸参与心脏钙稳态调控机制的研究现状

发布时间：2018-05-04 16:01

本文选题：钙稳态 + 非编码核糖核酸　；参考：《中国临床药理学杂志》2017年11期

【摘要】：心血管疾病发生率和致死率逐年增加,而目前的治疗手段仍不足以解决这一现状。Ca~(2+)是重要的第二信使,其稳态失衡会导致细胞功能障碍和代谢紊乱,从而引起心脏功能异常,如心肌肥厚、心房纤颤、心肌缺血与心力衰竭等心血管疾病。兰尼碱受体2(RyR2)、L型钙通道(LTCC)、钠钙交换体(NCX)以及腺苷三磷酸(ATP)依赖性钙泵(SERCA2a)等均能参与钙稳态的维持,然而更确切的调控机制仍未完全阐明,导致其在心血管疾病治疗与预防应用中存在局限。非编码核糖核酸(ncRNA)是一类不编码蛋白的核糖核酸(RNA),可参与多种生物学功能。阐明非编码RNA在钙稳态过程中的调控机制,有助于预测心房颤动等心脏疾病易感性、延缓病情进展及评估预后。本文对非编码RNA参与心脏疾病钙稳态调控机制研究进展进行综述。
[Abstract]:The incidence and mortality of cardiovascular diseases increase year by year, and the current treatment methods are not enough to solve this situation. Caan2) is an important second messenger. Its homeostasis can lead to cell dysfunction and metabolic disorder, which can lead to abnormal cardiac function. Such as myocardial hypertrophy, atrial fibrillation, myocardial ischemia and heart failure and other cardiovascular diseases. The L-type calcium channel of Lanni receptor 2N RyR2CX, sodium calcium exchanger NCX, and adenosine triphosphate ATP dependent calcium pump SERCA2a) can participate in the maintenance of calcium homeostasis. However, the more precise regulation mechanism has not been fully elucidated. These results in the limitation of its application in the treatment and prevention of cardiovascular diseases. Noncoding ribonucleic acid (ncRNAs) is a class of noncoding protein ribonucleic acid RNA (RNAs), which can participate in many biological functions. To elucidate the regulatory mechanism of noncoding RNA during calcium homeostasis is helpful to predict the susceptibility of atrial fibrillation and other heart diseases, delay the progression of the disease and evaluate the prognosis. This review reviews the progress of non-coding RNA in the regulation of calcium homeostasis in heart disease.
【作者单位】：哈尔滨医科大学药理教研室;
【基金】：国家自然科学基金资助项目(81673426)
【分类号】：R54

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